CD33, CD33 molecule, 945

N. diseases: 142; N. variants: 6
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.060 AlteredExpression disease BEFREE Moreover, genome-wide association studies have linked variants in several immune genes, such as TREM2 and CD33, the expression of which in the brain is restricted to microglia, with cognitive dysfunctions in LOAD. 28185874 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.060 GeneticVariation disease BEFREE Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. 26621708 2016
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.060 GeneticVariation disease BEFREE We also identified a block of eight correlated SNPs in CD33 and several blocks of correlated SNPs in CELF1 that were significantly associated with cognitive decline in univariate analysis in the all-female cohort. 27005436 2016
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.060 GeneticVariation disease BEFREE Among those with one or more APOE ε4 alleles, having one or more copies of the CD33 C (risk) allele may further increase the risk of cognitive decline. 26102276 2015
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.060 GeneticVariation disease BEFREE The incident case study comparing patients who developed AD during longitudinal observation (n = 152) with participants with no cognitive impairment found that rs2075650 (TOMM40) and rs3865444 (CD33) influence the risk of developing AD in this population. 24176626 2014
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.060 AlteredExpression disease BEFREE We found that ABCA7, CD33, and CR1 expression levels were associated with clinical dementia rating (CDR), with higher expression being associated with more advanced cognitive decline. 23226438 2012