ATG5, autophagy related 5, 9474

N. diseases: 282; N. variants: 36
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 AlteredExpression disease BEFREE Interestingly, no E3-like conjugation activity of ATG5-12/16L1 can be detected at the at HCV replication site since LC3B-II is not found along with the elongation complex at the site of viral replication. 30286180 2018
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE We also confirmed that LC3-positive dots were co-localized with ubiquitinated aggregates, and deficiency of ATG5 or ATG14 enhanced the accumulation of ubiquitinated aggregates compared to that in the restored cells, suggesting that HCV infection induces ATG5- and ATG14-dependent selective autophagy. 30311874 2018
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE Furthermore, purification of HCV MW revealed the presence of ATG5-12 and ATG16L1 along with HCV nonstructural proteins. 28067309 2017
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 AlteredExpression disease BEFREE Overexpression of ATG5 and/or GABARAP could partly recover the IFN-λ1-inhibited HCV replication. 28131804 2017