|
Malignant neoplasm of prostate
|
0.330 |
Biomarker
|
disease |
BEFREE |
Collectively, these results highlight the synergy between ONECUT2 and hypoxia in driving NEPC, and emphasize the potential of hypoxia-directed therapy for NEPC patients.
|
30655535 |
2019 |
|
Malignant neoplasm of prostate
|
0.330 |
Biomarker
|
disease |
BEFREE |
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
|
30478421 |
2018 |
|
Malignant neoplasm of prostate
|
0.330 |
Biomarker
|
disease |
CTD_human |
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.
|
29581250 |
2018 |
|
Malignant neoplasm of prostate
|
0.330 |
Biomarker
|
disease |
BEFREE |
After quantitative PCR analysis on tissue specimens and urinary sediments, eight promising biomarkers for the urinary detection of prostate cancer were selected (ONECUT2, HOXC4, HOXC6, DLX1, TDRD1, NKAIN1, MS4A8B, PPFIA2).
|
25788493 |
2015 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.
|
29581250 |
2018 |
|
Prostate carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these results highlight the synergy between ONECUT2 and hypoxia in driving NEPC, and emphasize the potential of hypoxia-directed therapy for NEPC patients.
|
30655535 |
2019 |
|
Prostate carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
|
30478421 |
2018 |
|
Prostate carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
After quantitative PCR analysis on tissue specimens and urinary sediments, eight promising biomarkers for the urinary detection of prostate cancer were selected (ONECUT2, HOXC4, HOXC6, DLX1, TDRD1, NKAIN1, MS4A8B, PPFIA2).
|
25788493 |
2015 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Targeting these adaptation mechanisms along with chemotherapy, such as by blocking the EV miRNA-ONECUT2 axis, represents a potential strategy to maximize the anticancer effect of chemotherapy and to reduce chemoresistance in cancer management.
|
31118200 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Targeting these adaptation mechanisms along with chemotherapy, such as by blocking the EV miRNA-ONECUT2 axis, represents a potential strategy to maximize the anticancer effect of chemotherapy and to reduce chemoresistance in cancer management.
|
31118200 |
2019 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Blockade of ONECUT2 expression in ovarian cancer inhibited tumor cell proliferation, migration, invasion and angiogenesis.
|
29737581 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Twelve CpG islands (AR, CDKN1C, DLC1, DRD2, GATA4, GDNF, GRIN2B, MTHFR, MYOD1, NEUROD1, ONECUT2 and TFAP2A) showed significant methylation in over 85% of tumors.
|
18288132 |
2008 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
An increase in gene expression was rare, but found with the transcription factor ONECUT2 gene in all of the cancer cell lines examined.
|
17523142 |
2007 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
An increase in gene expression was rare, but found with the transcription factor ONECUT2 gene in all of the cancer cell lines examined.
|
17523142 |
2007 |
|
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ONECUT2 ectopic expression in prostate adenocarcinoma synergizes with hypoxia to suppress androgen signaling and induce neuroendocrine plasticity.
|
30655535 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study indicated that THUMPD3-AS1 regulated NSCLC cell self-renewal by regulating the expression of miR-543 and ONECUT2, and THUMPD3-AS1 can potentially act as a biomarker or therapeutic target in NSCLC.
|
31819483 |
2019 |
|
Neuroendocrine Tumors
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Through pan-NET analyses, we identified ONECUT2 as a candidate master transcriptional regulator of poorly differentiated NETs.
|
30655535 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Shared causal polymorphisms in the Deleted in Colorectal Carcinoma, Netrin 1 receptor (DCC) gene were found in one multiplex family with three patients, and variants in the RNA 3'-Terminal Phosphate Cyclase (RTCA) and One Cut Homeobox 2 (ONECUT2) genes were found to be shared in seven patients.
|
30323194 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of OC2 by a newly identified small molecule suppresses metastasis in mice.
|
30478421 |
2018 |
|
Metastatic castration-resistant prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we identify the transcription factor ONECUT2 (OC2) as a master regulator of AR networks in metastatic castration-resistant prostate cancer (mCRPC).
|
30478421 |
2018 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Most importantly, comparison of each of the brain tumor type-specific networks revealed a network unique to PA that included repressed expression of ONECUT2, a gene frequently methylated in other tumor types, and 13 other uniquely predicted TF-gene interactions.
|
21745356 |
2011 |
|
Pilocytic Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Most importantly, comparison of each of the brain tumor type-specific networks revealed a network unique to PA that included repressed expression of ONECUT2, a gene frequently methylated in other tumor types, and 13 other uniquely predicted TF-gene interactions.
|
21745356 |
2011 |
|
B-Cell Lymphomas
|
0.010 |
PosttranslationalModification
|
group |
LHGDN |
DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status.
|
18288132 |
2008 |
|
Waardenburg Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results show that OC-2 stimulates MITF expression and that OC2 is a candidate gene, but not a common cause, of WS.
|
11478782 |
2001 |