GDF15, growth differentiation factor 15, 9518

N. diseases: 389; N. variants: 3
Disease: Secondary malignant neoplasm of bone ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.070 Biomarker disease BEFREE They also suggest that targeting of GDF15-based and EGR1-based signaling pathways should be further explored for their potential to diminish progression of PCa bone metastasis. 30755731 2019
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.070 GeneticVariation disease BEFREE The growth differentiation factor 15 (GDF15) gene which may be associated with bone metastasis of lung cancer, was screened out by whole‑genome sequencing. 30816507 2019
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.070 Biomarker disease BEFREE We identified growth differentiation factor-15 as the best individual marker for bone metastasis diagnostics. 30343636 2018
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.070 AlteredExpression disease BEFREE Higher levels (p<0.0001) of MIC1/GDF15 were found in group 1 (with bone metastases) compared to the group 0. 28314325 2017
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.070 Biomarker disease BEFREE New GDF-15 roles have recently been identified for modulating osteoclast differentiation and for therapy for PCa bone metastases. 22370725 2012
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.070 Biomarker disease BEFREE The effects of MIC-1 on prostate cancer bone metastases are unknown. 19152406 2009
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.070 Biomarker disease BEFREE These results unveil new role of GDF-15 in modulation of osteoclast differentiation and possibly in therapy of bone metastases. 19695766 2009