|
ESTROGEN RESISTANCE
|
0.100 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Dendritic cell-derived factor 1 (Dcf1) is known to play an important role in neural stem cell differentiation, glioma apoptosis, dendritic spine formation, and Alzheimer's disease (AD), nevertheless, the involvement of the <i>Dcf1</i> gene in the brain immune response has not yet been reported.
|
30104955 |
2018 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Such alteration derails the intracellular trafficking of TMEM59 and the xenophagic response against bacterial infection.
|
27541200 |
2016 |
|
Bacterial Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Such alteration impairs the unconventional autophagic activity of TMEM59, a transmembrane protein that contains the WD40 domain-binding motif, and disrupts its normal intracellular trafficking and its ability to engage ATG16L1 in response to bacterial infection.
|
27273576 |
2016 |
|
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of DCF1 inhibits glioma through destruction of mitochondria and activation of apoptosis pathway.
|
24424470 |
2014 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dcf1 Affects Memory and Anxiety by Regulating NMDA and AMPA Receptors.
|
31531752 |
2019 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Dcf1 Affects Memory and Anxiety by Regulating NMDA and AMPA Receptors.
|
31531752 |
2019 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
All the results indicated that DCF1 could be a potential therapeutic target for the understanding and treatment of NB.
|
30365123 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
All the results indicated that DCF1 could be a potential therapeutic target for the understanding and treatment of NB.
|
30365123 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
All the results indicated that DCF1 could be a potential therapeutic target for the understanding and treatment of NB.
|
30365123 |
2019 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dendritic cell-derived factor 1 (Dcf1) is known to play an important role in neural stem cell differentiation, glioma apoptosis, dendritic spine formation, and Alzheimer's disease (AD), nevertheless, the involvement of the <i>Dcf1</i> gene in the brain immune response has not yet been reported.
|
30104955 |
2018 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these findings suggest that the TAT-DCF1 fusion protein was efficiently transduced into Glioblastoma U251 cells and induced the antitumor effect and support further investigation into specific targeting and side effects of TAT-DCF1 during drug delivery.
|
30001801 |
2018 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings revealed an important role of DCF1 in PD process and may provide new potential strategies for developing drugs to treat neurodegenerative diseases.
|
29649746 |
2018 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these findings suggest that the TAT-DCF1 fusion protein was efficiently transduced into Glioblastoma U251 cells and induced the antitumor effect and support further investigation into specific targeting and side effects of TAT-DCF1 during drug delivery.
|
30001801 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these findings suggest that the TAT-DCF1 fusion protein was efficiently transduced into Glioblastoma U251 cells and induced the antitumor effect and support further investigation into specific targeting and side effects of TAT-DCF1 during drug delivery.
|
30001801 |
2018 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our findings revealed an important role of DCF1 in PD process and may provide new potential strategies for developing drugs to treat neurodegenerative diseases.
|
29649746 |
2018 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these findings suggest that the TAT-DCF1 fusion protein was efficiently transduced into Glioblastoma U251 cells and induced the antitumor effect and support further investigation into specific targeting and side effects of TAT-DCF1 during drug delivery.
|
30001801 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Dendritic cell factor 1 plays important roles in neural stem cells differentiation and in glioma cells proliferation, migration, and invasion.
|
26025395 |
2015 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The present study identified a previously unknown cancer apoptosis mechanism involving dcf1 overexpression and provided a novel approach to potentially treat glioma patients.
|
24424470 |
2014 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The present study identified a previously unknown cancer apoptosis mechanism involving dcf1 overexpression and provided a novel approach to potentially treat glioma patients.
|
24424470 |
2014 |
|
Staphylococcus aureus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endogenous TMEM59 interacts with ATG16L1 and mediates autophagy in response to Staphylococcus aureus infection.
|
23376921 |
2013 |
|
Alzheimer Disease, Late Onset
|
0.010 |
Biomarker
|
disease |
BEFREE |
The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-β protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology.
|
22451312 |
2012 |