TMEM59, transmembrane protein 59, 9528

N. diseases: 20; N. variants: 2
Disease: Bacterial Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.020 Biomarker group BEFREE Such alteration derails the intracellular trafficking of TMEM59 and the xenophagic response against bacterial infection. 27541200 2016
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.020 AlteredExpression group BEFREE Such alteration impairs the unconventional autophagic activity of TMEM59, a transmembrane protein that contains the WD40 domain-binding motif, and disrupts its normal intracellular trafficking and its ability to engage ATG16L1 in response to bacterial infection. 27273576 2016