Cardiomyopathy, Dilated
|
0.400 |
Biomarker
|
group |
BEFREE |
The significant role of BAG3 in protecting cardiomyocytes provides a new direction for the diagnosis and treatment of dilated cardiomyopathy.
|
31808029 |
2019 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes.
|
31723063 |
2019 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Here, we studied whether a clinical association between BAG3-related FDCM and circulating miRNAs may have diagnostic and prognostic value in a small cohort of familial related individuals carrying a BAG3 mutation (BAG3+) and/or diagnosed of dilated cardiomyopathy (DCM) (DCM+).
|
30792263 |
2019 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations of BAG3 have been implicated in the pathogenesis of cardiac complications such as dilated cardiomyopathy.
|
30932190 |
2019 |
Cardiomyopathy, Dilated
|
0.400 |
Biomarker
|
group |
BEFREE |
This study demonstrates that genetic variants in BAG3 found almost exclusively in individuals of African ancestry were not causative of disease but were associated with a negative outcome in patients with a dilated cardiomyopathy through modulation of the function of BAG3.
|
30140897 |
2018 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This study sought to describe the phenotype and prognosis of BAG3 mutations in a large multicenter DCM cohort.
|
30442290 |
2018 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Deletions and truncations in BAG3 that result in haplo-insufficiency have been associated with the development of dilated cardiomyopathy.
|
29323723 |
2018 |
Cardiomyopathy, Dilated
|
0.400 |
CausalMutation
|
group |
CLINVAR |
Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.
|
28737513 |
2017 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutation and downregulation of the co-chaperone protein BCL-2-associated athanogene 3 (BAG3) are associated with cardiac myopathy and heart failure, and a BAG3 E455K mutation leads to dilated cardiomyopathy (DCM).
|
28737513 |
2017 |
Cardiomyopathy, Dilated
|
0.400 |
Biomarker
|
group |
BEFREE |
In this issue of the JCI, Fang and colleagues demonstrate that mice with cardiac-specific deficiency of the co-chaperone protein BCL2-associated athanogene 3 (BAG3) develop dilated cardiomyopathy that is associated with a destabilization of small HSPs as the result of a disrupted interaction between BAG3 and HSP70.
|
28737514 |
2017 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Whole exome sequencing identified 1 base pair novel deletion in BCL2-associated athanogene 3 (BAG3) gene associated with severe dilated cardiomyopathy (DCM) requiring heart transplant in multiple family members.
|
28211974 |
2017 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Novel Genetic Variants in BAG3 and TNNT2 in a Swedish Family with a History of Dilated Cardiomyopathy and Sudden Cardiac Death.
|
28669108 |
2017 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
At least 10 other Bag3 mutations have been reported, nine resulting in a dilated cardiomyopathy for which no specific therapy is available.
|
27321750 |
2016 |
Cardiomyopathy, Dilated
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Thus, it becomes relevant to understand the cellular biology and molecular regulation of BAG3 expression in order to design new therapies for the treatment of patients with both hereditary and non-hereditary forms of dilated cardiomyopathy.
|
25925243 |
2015 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
CLINVAR |
BAG3 myofibrillar myopathy presenting with cardiomyopathy.
|
25728519 |
2015 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
CLINVAR |
BAG3: a new player in the heart failure paradigm.
|
25925243 |
2015 |
Cardiomyopathy, Dilated
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Diminished levels of BAG3 protein may be associated with both familial and non-familial forms of dilated cardiomyopathy.
|
24623017 |
2014 |
Cardiomyopathy, Dilated
|
0.400 |
CausalMutation
|
group |
CLINVAR |
The BAG3 gene variants in Polish patients with dilated cardiomyopathy: four novel mutations and a genotype-phenotype correlation.
|
25008357 |
2014 |
Cardiomyopathy, Dilated
|
0.400 |
CausalMutation
|
group |
CLINVAR |
Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians.
|
25448463 |
2014 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The BAG3 gene variants in Polish patients with dilated cardiomyopathy: four novel mutations and a genotype-phenotype correlation.
|
25008357 |
2014 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians.
|
25448463 |
2014 |
Cardiomyopathy, Dilated
|
0.400 |
CausalMutation
|
group |
CLINVAR |
Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy.
|
24558114 |
2014 |
Cardiomyopathy, Dilated
|
0.400 |
CausalMutation
|
group |
CLINVAR |
Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era.
|
22337857 |
2012 |
Cardiomyopathy, Dilated
|
0.400 |
GeneticVariation
|
group |
GWASDB |
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.
|
21459883 |
2011 |
Cardiomyopathy, Dilated
|
0.400 |
CausalMutation
|
group |
CLINVAR |
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.
|
21459883 |
2011 |