Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis
0.310 Biomarker disease CTD_human Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. 15651265 2004
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis
0.310 AlteredExpression disease LHGDN Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. 15651265 2004
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.300 Biomarker disease CTD_human Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. 15651265 2004
CUI: C0238065
Disease: Secondary Biliary Cholangitis
Secondary Biliary Cholangitis
0.300 Biomarker disease CTD_human Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. 15651265 2004
CUI: C4551595
Disease: Biliary Cirrhosis, Primary, 1
Biliary Cirrhosis, Primary, 1
0.300 Biomarker disease CTD_human Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. 15651265 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.200 Biomarker group RGD L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats. 20655932 2010
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.200 Biomarker disease RGD Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. 15651265 2004
CUI: C0341858
Disease: Endometriosis of uterus
Endometriosis of uterus
0.010 AlteredExpression disease BEFREE The aim of this study was to characterize the expression of NTPDase2 in human nonpathological cyclic and postmenopausic endometria and in adenomyosis. 31123897 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker phenotype BEFREE Extracellular ATP is mainly hydrolyzed by NTPDase1/CD39 and NTPDase2/CD39L1, generating AMP, which is hydrolyzed by ecto-5'-nucleotidase (CD73) to adenosine, a possible promoter of tumor growth and metastasis. 29455338 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 Biomarker disease BEFREE After chronic CCl<sub>4</sub> intoxication, Entpd2 null mice exhibit significantly more severe liver fibrosis, as assessed by collagen content and histology. 29134411 2018
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder
0.010 Biomarker phenotype BEFREE Liver regeneration after partial hepatectomy is not substantively impaired in global Entpd2 null mice. 29134411 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE Our data suggest that ENTPD2 may be a good prognostic marker and therapeutic target for cancer patients, especially those receiving immune therapy.Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. 28894087 2017
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.010 Biomarker disease BEFREE The preservation of the proportion of GFAP single-labeled and GFAP/NTPDase2 double-labeled elements along the course of EAE indicated that changes in NTPDase2-<i>ir</i> occurred at fibrous astrocytes that typically express NTPDase2 in normal conditions. 29163045 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 Biomarker group BEFREE Our data suggest that ENTPD2 may be a good prognostic marker and therapeutic target for cancer patients, especially those receiving immune therapy.Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. 28894087 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker group BEFREE Our data suggest that ENTPD2 may be a good prognostic marker and therapeutic target for cancer patients, especially those receiving immune therapy.Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. 28894087 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.010 AlteredExpression disease BEFREE Overexpression of ENTPD2 is found as a poor prognostic indicator for HCC. 28894087 2017
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.010 Biomarker disease BEFREE Transcripts of ectonucleotidases (CD39 and CD39L1) together with P2R (P2X7, P2Y2, and P2Y6) are significantly increased in both chronic pancreatitis and pancreatic cancer. 16920697 2007
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 Biomarker disease BEFREE Transcripts of ectonucleotidases (CD39 and CD39L1) together with P2R (P2X7, P2Y2, and P2Y6) are significantly increased in both chronic pancreatitis and pancreatic cancer. 16920697 2007