|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.
|
26830138 |
2016 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Rab3D is a member of the ras-related GTP-binding protein Rab family and was found up-regulated in several types of cancer.
|
28472755 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Exercise represents a potential cardiac risk reduction intervention for cancer survivors.CLINICAL TRIALS.GOV: NCT01102985.
|
28803675 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Rab3D is a member of the ras-related GTP-binding protein Rab family and was found up-regulated in several types of cancer.
|
28472755 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Exercise represents a potential cardiac risk reduction intervention for cancer survivors.CLINICAL TRIALS.GOV: NCT01102985.
|
28803675 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Rab3D belongs to Rab protein family.Previous reports showed that the expression of Rab3D was dysregulated in various types of cancer.Rab3D belongsRab3D belongs.
|
27046094 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Rab3D belongs to Rab protein family.Previous reports showed that the expression of Rab3D was dysregulated in various types of cancer.Rab3D belongsRab3D belongs.
|
27046094 |
2016 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Here, we reported that the expression levels of Rab3D were dysregulated in cancer cells and highly correlated with tumor malignancies in the clinical samples.
|
25823663 |
2015 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We detected protein levels of Rab3D in nine cancer cell lines and twelve types of clinical cancer specimens.
|
25823663 |
2015 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
<b>Conclusion:</b> Our study elucidated the role of a new HOXA11-AS/miR-125a-5p/Rab3D regulatory pathway in promoting OS metastasis.
|
31191012 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that miR-506-3p acts as a tumor suppressor in osteosarcoma and that its downregulation leads to tumor cell proliferation and metastasis due to upregulation of RAB3D- and CDK4-mediated signaling. miR-506-3p thus appears be a potentially useful target for adjuvant therapy in osteosarcoma patients.
|
29905536 |
2018 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that miR-506-3p acts as a tumor suppressor in osteosarcoma and that its downregulation leads to tumor cell proliferation and metastasis due to upregulation of RAB3D- and CDK4-mediated signaling. miR-506-3p thus appears be a potentially useful target for adjuvant therapy in osteosarcoma patients.
|
29905536 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
And Rab3D partly reversed the suppression of cell proliferation and invasion caused by miR-27b mimics.
|
29423086 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Investigator-assessed response rates showed high rate of tumour control.CLINICALTRIALS.GOV: NCT01367665.
|
29073584 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data demonstrated that Rab3D functions as an oncogene in ESCC and knockdown of Rab3D suppressed ESCC cell proliferation and invasion, potentially through the PI3K/Akt signaling pathway.
|
28472755 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Subsequently, we established in vitro migration and in vivo orthotopic metastatic mouse models to study the role of Rab3D in tumor metastasis.
|
25823663 |
2015 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Here, we reported that the expression levels of Rab3D were dysregulated in cancer cells and highly correlated with tumor malignancies in the clinical samples.
|
25823663 |
2015 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Increased expressions of Rab3D led to tumor invasion in vitro and lung metastasis in vivo, whereas Rab3D knockdown suppressed the tumor cell motility.
|
25823663 |
2015 |
|
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> Our study elucidated the role of a new HOXA11-AS/miR-125a-5p/Rab3D regulatory pathway in promoting OS metastasis.
|
31191012 |
2019 |
|
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> Our study elucidated the role of a new HOXA11-AS/miR-125a-5p/Rab3D regulatory pathway in promoting OS metastasis.
|
31191012 |
2019 |
|
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> Our study elucidated the role of a new HOXA11-AS/miR-125a-5p/Rab3D regulatory pathway in promoting OS metastasis.
|
31191012 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our study implied miR-27b inhibits cell growth and invasion by targeting Rab3D, and miR-27b is a potential biomarker for prognosis and therapeutic target in colorectal cancer.
|
29423086 |
2018 |
|
Osteosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that miR-506-3p acts as a tumor suppressor in osteosarcoma and that its downregulation leads to tumor cell proliferation and metastasis due to upregulation of RAB3D- and CDK4-mediated signaling. miR-506-3p thus appears be a potentially useful target for adjuvant therapy in osteosarcoma patients.
|
29905536 |
2018 |
|
Osteosarcoma of bone
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that miR-506-3p acts as a tumor suppressor in osteosarcoma and that its downregulation leads to tumor cell proliferation and metastasis due to upregulation of RAB3D- and CDK4-mediated signaling. miR-506-3p thus appears be a potentially useful target for adjuvant therapy in osteosarcoma patients.
|
29905536 |
2018 |
|
Childhood Osteosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that miR-506-3p acts as a tumor suppressor in osteosarcoma and that its downregulation leads to tumor cell proliferation and metastasis due to upregulation of RAB3D- and CDK4-mediated signaling. miR-506-3p thus appears be a potentially useful target for adjuvant therapy in osteosarcoma patients.
|
29905536 |
2018 |