Fibrosis, Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our previous work showed that DZP suppresses CCl-4 induced hepatic fibrosis by downregulating the expression of interleukin-13.
|
30986521 |
2019 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the effects of IL-1β on human hepatic stellate cells (HSC) and in mouse models of liver fibrosis induced by bile duct ligation (BDL) or carbon tetrachloride treatment (CCl-4).
|
30875826 |
2019 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
As reversible deacetylation of histone proteins modulate gene expression, we examined the effect of valproic acid (VPA) as selective histone deacetylase inhibitor on CCl-4 induced liver fibrosis.
|
29601129 |
2018 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have indicated that female animals are more resistant to carbon tetrachloride (CCl(4))-induced liver fibrosis than male animals, and that estradiol (E(2)) treatment can inhibit CCl(4)-induced animal hepatic fibrosis.
|
22393047 |
2012 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Acupuncture treatment could significantly enhance the antifibrotic efficacy of curcumin on CCl(4)-induced hepatic fibrosis in rats in vivo, suggesting that a combination of acupuncture with curcumin may be exploited for the prevention of hepatic fibrosis.
|
22366645 |
2012 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that human peripheral blood CD34(+) cell transplantation halts established liver fibrosis and promotes hepatic regeneration in CCl(4)-induced chronic liver injury.
|
21678408 |
2012 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, azelnidipine prevented a decrease in the expression of some antioxidant enzymes and accelerated regression of liver fibrosis in CCl(4) -treated mice.
|
21790536 |
2012 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent with the enhanced activation of CtsB in HSCs from ASMase-null mice, the in vivo liver fibrosis induced by chronic treatment with CCl(4) increased in ASMase-null compared with wild-type mice, an effect that was reduced upon CtsB inhibition.
|
22102288 |
2012 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo study, experimental liver fibrosis models were built by carbon tetrachloride (CCl(4)) or common bile duct ligation (CBDL) in Wistar rats.
|
21726622 |
2011 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
We systematically analyzed the regulation of miRNAs in a mouse model of carbon tetrachloride-induced hepatic fibrogenesis (CCl(4) ) by gene array analysis, which revealed a panel of miRNA that were specifically regulated in livers of mice undergoing hepatic fibrosis.
|
20890893 |
2011 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Liver fibrosis was induced in male Wistar rats by administration of carbon tetrachloride (CCl(4)) for 10 weeks.
|
21849805 |
2011 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a CCL(4)-induced mouse liver fibrosis model, we compared the miRNA expression profile from CCL(4) and olive oil administrated liver specimens on 4, 6, and 8 weeks.
|
21283674 |
2011 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following chronic CCl(4) administration, liver fibrosis was analyzed using Sirius Red staining with quantitative morphometry and real-time polymerase chain reaction (PCR) in MMP-2-/- mice and age-matched MMP-2+/+ controls.
|
20563750 |
2011 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blueberry has preventive and protective effects on CCl(4)-induced hepatic fibrosis by reducing hepatocyte injury and lipid peroxidation.
|
20518088 |
2010 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we confirmed an important role of the inflammasome in experimental liver fibrosis by the injection of carbon tetrachloride (CCl(4)) or thioacetamide (TAA) in wild-type mice and mice lacking components of the inflammasome.
|
19359429 |
2009 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
FXR loss had no effect in CCl(4)-intoxicated and S.m.-infected mice, but significantly decreased liver fibrosis of the biliary type (common bile duct ligation, 3,5-diethoxycarbonyl-1,4-dihydrocollidine).
|
19910507 |
2009 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Liver fibrosis was induced in BALB/c mice by either carbon tetrachloride (CCl(4)) or bile duct ligation (BDL).
|
18823985 |
2008 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
An in vivo model of carbon tetrachloride (CCl(4))-induced liver fibrosis was used.
|
18627004 |
2008 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
These events provide a clearer rationale as to how Ad-huPA-induced liver regeneration on CCl(4)-induced liver fibrosis takes place.
|
16958060 |
2006 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
TA in both male and female rats with CCl(4) induced liver fibrosis was significantly higher with oestradiol administration than without (p<0.05).
|
15194652 |
2004 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Between 3 and 7 days of resolution from CCl(4) liver fibrosis, MMP-2 and MMP-14 persisted at elevated levels.
|
15482348 |
2004 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatocytes isolated from normal Sprague-Dawley (SD) rats were transfected with an adenoviral vector encoding human IFN-gamma gene (AdCMVhIFN-gamma) and transplanted into the spleens of syngenic recipients with ongoing liver fibrosis induced by carbon tetrachloride (CCl(4)).
|
12389079 |
2002 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
After 4-week treatment with CCl(4), however, densitometric analysis revealed that TIMP-Tg-mice had a seven-fold increase in liver fibrosis compared with the Cont-mice.
|
11093731 |
2000 |
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Quantification of CTGF mRNA by a real-time reverse-transcription polymerase chain reaction (RT-PCR) assay showed a significant increase of CTGF mRNA in both CCl(4)-induced and bile duct-ligated rat models of liver fibrosis.
|
10498649 |
1999 |
Hepatitis C
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In particular, lower MIP-1β (≤71.5 pg/mL) and higher RANTES (>671.5 pg/mL) levels were significantly associated with patients who failed to clear HCV RNA (P = 0.0039 and 0.013, respectively).
|
30296712 |
2018 |