|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Small molecule inhibitors of CD40-TRAF6 have shown to be effective in multiple animal-models of chronic inflammatory disease, such as obesity and atherosclerosis.
|
30612848 |
2019 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the C allele of the -1T>C SNP of the CD40 gene (rs1883832) results in an enhanced CD40 surface abundance and pro-inflammatory phenotype of vascular endothelial cells, increasing the susceptibility to atherosclerosis and CHD in humans.This appears to be compensated by an enhanced shedding of sCD40 from the endothelial cell membrane to neutralize excess CD40 ligand. sCD40 might be a potential new biomarker for the pro-inflammatory processes occurring in atherosclerosis.
|
31373353 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
TRAF-STOPs can overcome the current limitations of long-term CD40 inhibition in atherosclerosis and have the potential to become a future therapeutic for atherosclerosis.
|
29406859 |
2018 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Platelet CD40 Mediates Leukocyte Recruitment and Neointima Formation after Arterial Denudation Injury in Atherosclerosis-Prone Mice.
|
29037856 |
2018 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The mechanism by which FO B cells promote atherosclerosis is highly dependent on their expression of MHCII, CD40, and Blimp-1.
|
29599140 |
2018 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, the effects of constitutively active CD40 in DCs on atherosclerosis were examined using low-density lipoprotein-deficient (Ldlr<sup>-/-</sup>) bone marrow chimeras that express a transgene containing an engineered latent membrane protein 1 (LMP)/CD40 fusion protein conferring constitutive CD40 signaling under control of the DC-specific CD11c promoter (DC-LMP1/CD40).
|
28935569 |
2017 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis.
|
27835742 |
2016 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Platelet CD40 plays a crucial role in inflammation by stimulating leukocyte activation and recruitment and activation of endothelial cells, thereby promoting atherosclerosis.
|
26821950 |
2016 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and inflammation during atherosclerosis.
|
24664276 |
2014 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP) rs1883832 (-1C/T) in CD40 gene has been recently suggested to contribute to the susceptibility to atherosclerosis in Chinese population; however, previous genetic association studies yielded inconsistent results.
|
24828072 |
2014 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
This potent and selective peptide ligand has potential for targeted imaging and drug delivery approaches in CD40-dependent inflammatory disorders such as atherosclerosis.
|
23896727 |
2013 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
A role of CD40 (cluster of differentiation 40) is suggested in development of atherosclerosis plaques, especially in advanced plaques.
|
21640399 |
2013 |
|
Atherosclerosis
|
0.300 |
Therapeutic
|
disease |
RGD |
We aimed to investigate whether atorvastatin influenced the CD40-CD40L pathway in atherosclerosis formation in rats fed a high cholesterol diet.
|
23984971 |
2013 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Although we did not observe a significant association of CD40-CD154 gene variants with the development of CV events, an ANCOVA model adjusted for sex, age at the time of the ultrasonography assessment, follow-up time, traditional CV risk factors and anti-cyclic citrullinated peptide antibodies disclosed a significant association (p=0.0047) between CD40 rs1535045 polymorphism and carotid intima media thickness, a surrogate marker of atherosclerosis.
|
23166616 |
2012 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CTSS mRNA levels correlated with CD40 mRNA levels, independently of observed traditional risk factors for atherosclerosis and pharmacological treatment.
|
21223957 |
2011 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
1.CD40 and CD40 ligand (CD40L) have a critical role in the pathophysiology and risk prediction of coronary artery syndrome, including atherothrombosis and atherosclerosis.
|
20456428 |
2010 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we illustrate the various functional features of these molecules, while describing the increasingly important role of CD40 in CD154-associated vascular pathologies such as atherosclerosis and atherothrombosis.
|
19282242 |
2009 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The interaction between CD40 and its ligand (CD40L) has been implicated in the pathogenesis of atherosclerosis and is recognized as a central event in the development of immuno-inflammatory processes.
|
19187784 |
2009 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD40/CD40L may participate in the development of coronary atherosclerosis and the triggering of acute coronary syndromes, while sCD40L seems to have a prognostic role not only in subjects with advanced atherosclerosis but also in the general population.
|
19679244 |
2009 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L have been implicated in atherosclerosis.
|
18285570 |
2008 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The CD40 receptor and its ligand (CD40L) are known to modulate both inflammation and thrombosis-2 processes important for the development and clinical expression of atherosclerosis.
|
19061720 |
2008 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
A role for CD40-CD40L interactions has been identified in atherosclerosis, and such interactions are known to destabilize atherosclerotic plaques by inducing the expression of cytokines, chemokines, growth factors, matrix metalloproteinases and pro-coagulant factors.
|
18977174 |
2008 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
RGD |
Our results suggest that the expression of CD40 and CD40L in the blood cells and the activities of MMP-2 and MMP-9 in plasma were higher in As group than those in Normal group, indicating that they may contribute to the formation of atherosclerosis.
|
16317521 |
2006 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Increasing evidence shows that CD40-CD40L interaction plays a crucial role in the pathogenesis of atherosclerosis and coronary artery disease.
|
14687897 |
2004 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis.
|
14517846 |
2003 |