|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between the CD40 rs1883832 polymorphism and Graves' disease risk: a meta-analysis.
|
30956635 |
2019 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD40 used to be associated with Graves's disease as positional candidate on the basis of Graves' disease linkage study connecting with 20q11 genome chromosomal region.
|
29325864 |
2018 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Correlation between CTLA-4 and CD40 gene polymorphisms and their interaction in graves' disease in a Chinese Han population.
|
30223781 |
2018 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Role of Different CD40 Polymorphisms in Graves' Disease and Hashimoto's Thyroiditis.
|
28742400 |
2017 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, CD40 stimulation robustly increased the expression of the NF-κB2 p52 transcription factor, and the upregulation was significantly more profound in the GD tissue than in the normal thyroid tissue.
|
27929668 |
2017 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest a possible additive combined effect between CD40-1C>T and CTLA4+6230G>A polymorphisms in the development of GD.
|
25936345 |
2015 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The CD40 gene, an important immune regulatory gene, is also expressed and functional on nonmyeloid-derived cells, many of which are targets for tissue-specific autoimmune diseases, including β cells in type 1 diabetes, intestinal epithelial cells in Crohn's disease, and thyroid follicular cells in Graves' disease (GD).
|
22888137 |
2012 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CD40 -1CC genotype and C allele were significantly more frequent in patients with Graves' disease (GD) in remission than in those with intractable GD (P = 0.041 and P = 0.031, respectively).
|
22706687 |
2012 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD40 levels on cultivated fibrocytes and orbital fibroblasts (GOFB) from patients with Graves' disease (GD), as well as fibrocyte abundance, were determined by flow cytometry.
|
23092922 |
2012 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis showed that CD40 C/T-1 polymorphism plays different roles in GD and HT.
|
22863718 |
2012 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, the CTLA-4, CD40, and PTPN22 loci do not harbor CNVs that play a role in the etiology of GD.
|
21054240 |
2011 |
|
Graves Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BALB/c mice were injected with PBS alone (PBS group), negative lentivirus (control siRNA group), or LV-CD40-siRNA (CD40 siRNA group), 3 days before being treated with adenovirus expressing human TSHR A subunit (Ad-TSHR289) three times at 3-week intervals to induce GD model.
|
21147892 |
2011 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A C/T polymorphism in CD40 gene is not associated with susceptibility and phenotype of Graves' disease in Taiwanese.
|
18446002 |
2008 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
These data suggest that the T/T genotype and T allele in the CD40 gene are more likely to be associated with late-onset GD in Taiwanese patients.
|
18755875 |
2008 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the T/T genotype and T allele in the CD40 gene are more likely to be associated with late-onset GD in Taiwanese patients.
|
18755875 |
2008 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The intrafamilial association and the case-control study showed no association between CD40 C/T-1 and GD.
|
17786592 |
2008 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Susceptible alleles of the CD40 and CTLA-4 genes are not associated with the relapse after antithyroid withdrawal in Graves' disease.
|
17949264 |
2007 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combined, our genetic and tissue expression data suggest that the CD40 Kozak SNP is specific for thyroid antibody production involved in the etiology of GD.
|
17344890 |
2007 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunized DR3 mice also permitted testing the TSHR-specific function of the CD40 single nucleotide polymorphism (C vs. T) associated with GD.
|
17199432 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CC+CT genotypes of the CD40-E1SNP were associated with the increased risk for GD (p = 0.015, odds ratio [OR] = 1.9).
|
16756465 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the SNP of CD40 gene is associated with susceptibility to later onset of GD in Japanese.
|
16127217 |
2005 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
These data suggest that the SNP of CD40 gene is associated with susceptibility to later onset of GD in Japanese.
|
16127217 |
2005 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results support the notion that CD40 C-1T polymorphism has a modest effect on genetic susceptibility to sporadic GD.
|
16279844 |
2005 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our results support the notion that CD40 C-1T polymorphism has a modest effect on genetic susceptibility to sporadic GD.
|
16279844 |
2005 |