CLCA2, chloride channel accessory 2, 9635

N. diseases: 36; N. variants: 1
Disease: Malignant neoplasm of breast ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.340 Biomarker disease BEFREE CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. 29463274 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.340 Biomarker disease BEFREE hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation. 19654313 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.340 Biomarker disease BEFREE On the other hand, treatment of breast cancer CLCA2-negative cell lines with demethylating agents was able to restore CLCA2 expression, suggesting an epigenetic inactivation of this gene. 14973555 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.340 Biomarker disease BEFREE Our results suggest that CLCA2 may act as a tumor suppressor in breast cancer. 10554024 1999
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.340 GeneticVariation disease UNIPROT