|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection.
|
15288002 |
2004 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemically defined immune cell subtypes, i.e. those expressing T-cell markers (CD3, CD8, and FOXP3), a B-cell marker (CD20) and a histiocytic marker (CD68), were evaluated in a large series (n = 1165) of invasive BCs.
|
29947077 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
While the greatest percentage (~70%) of CD68+ and CD163+ pixels was 0-20 microns away from tumor and T cell borders, CD11b+ and CD11c+ pixels were detected up to 240 microns away from tumor/T cell masks.
|
30619287 |
2018 |
|
Sex hormone binding globulin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
|
22829776 |
2012 |
|
Estradiol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
|
22829776 |
2012 |
|
Serum albumin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.
|
22558069 |
2012 |
|
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemically defined immune cell subtypes, i.e. those expressing T-cell markers (CD3, CD8, and FOXP3), a B-cell marker (CD20) and a histiocytic marker (CD68), were evaluated in a large series (n = 1165) of invasive BCs.
|
29947077 |
2018 |
|
Estradiol level result
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
|
22829776 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Renal biopsy specimens from 23 patients with noninsulin-dependent diabetes mellitus (NIDDM) were examined by immunoperoxidase methods for CD68+ macrophages and alphaSMA and vimentin staining in paraffin-embedded samples. alphaSMA staining was evaluated in mesangial and interstitial myofibroblastic cells, and vimentin staining was evaluated in podocytes and mesangial and tubular cells.
|
17009076 |
2006 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to evaluate the role of EAT and MAT 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and glucocorticoid receptor (GCR) expression in comparison with subcutaneous adipose tissue (SAT) in the development of coronary atherosclerosis in obese patients with coronary artery disease (CAD), and to assess their correlations with CD68 and fatty acids from these tissues.
|
23009206 |
2012 |
|
Hernia
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Remarkably, MSC transplantation resulted in local downregulation of the hypoxia responsive GLUT-1 and in significantly less herniation, with higher amounts of Pax5+ B lymphocytes and no alterations in CD68+ macrophages within the hernia.
|
28297581 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Tumor Microenvironment Properties are Associated With Low CD68-positive Cell Infiltration and Favorable Disease-free Survival in EGFR-mutant Lung Adenocarcinoma.
|
29628320 |
2018 |
|
Human papilloma virus infection
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
<i>Results.</i> High counts of CD68+ and CD163+ macrophages were associated with hr-HPV infection (both <i>p</i> < 0.05) and positively correlated with cervical carcinogenesis (Spearman's rho = 0.478, <i>p</i> = 0.000; Spearman's rho = 0.676, <i>p</i> =0.000, respectively).
|
29151975 |
2017 |
|
Sarcoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We stress the importance of the CD68 marker in the diagnosis of true histiocytic lymphoma, suggest a therapeutic approach based on similarities with monocytic leukemia, and propose the use of the term monocytic sarcoma for this clinicopathological presentation.
|
1471748 |
1992 |
|
Coronary Artery Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to evaluate the role of EAT and MAT 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and glucocorticoid receptor (GCR) expression in comparison with subcutaneous adipose tissue (SAT) in the development of coronary atherosclerosis in obese patients with coronary artery disease (CAD), and to assess their correlations with CD68 and fatty acids from these tissues.
|
23009206 |
2012 |
|
Hydronephrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Clinical T3 stage (Hazard Ratio [HR] 1.6, Confidence Interval [CI] 1.1-2.3), hydronephrosis (HR 1.7, CI 1.2-2.3), lymphovascular invasion (LVI) (HR 2.6, CI 1.9-3.6), extensive necrosis (HR 1.6, CI 1.1-2.5), and CD68/CD3-ratio >1 (HR 1.3, CI 1.1-1.5) in the transurethral resection of bladder tumor specimen was associated with worse cancer-specific survival (CSS) and progression-free survival (data not shown).
|
31056435 |
2019 |
|
Familial Cerebral Amyloid Angiopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Arterial and arteriolar amyloid-beta (A beta) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using A beta, a-smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry.
|
9056541 |
1997 |
|
AURAL ATRESIA, CONGENITAL
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Arterial and arteriolar amyloid-beta (A beta) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using A beta, a-smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry.
|
9056541 |
1997 |
|
DIARRHEA 5, WITH TUFTING ENTEROPATHY, CONGENITAL
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, in a case-only analysis among CTE cases, the minor allele was associated with reduced phosphorylated tau (ptau) pathology in the dorsolateral frontal cortex (DLFC) (AT8 density, odds ratio [OR] of increasing one quartile = 0.42, 95% confidence interval [CI] 0.22-0.79, p = 0.008), reduced neuroinflammation in the DLFC (CD68 density, OR of increasing one quartile = 0.53, 95% CI 0.29-0.98, p = 0.043), and increased synaptic protein density (β = 0.306, 95% CI 0.065-0.546, p = 0.014).
|
30390709 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We stress the importance of the CD68 marker in the diagnosis of true histiocytic lymphoma, suggest a therapeutic approach based on similarities with monocytic leukemia, and propose the use of the term monocytic sarcoma for this clinicopathological presentation.
|
1471748 |
1992 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
CTD_human |
Expression levels of macrophage genes (CD68, CD11b, CD206, CD16, CD40, and CD163) were lower in skeletal muscle tissue of obese versus lean participants.
|
29035695 |
2018 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins.
|
16608891 |
2006 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
At baseline, SCAAT gene expression profile revealed a "co-upregulation" of MCP-1, MCP-2, macrophage inflammatory protein-1alpha, and CD68 in OB, and whole-body glucose disposal inversely correlated with the MCP-1 gene expression.
|
17456576 |
2007 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Relatively strong positive associations were seen with markers of inflammation, including CD68, macrophage chemoattractant protein-1, and plasminogen activator inhibitor (PAI)-1 mRNA (r >/= 0.46, P = 0.001 for each), that remained significant after controlling for BMI and S(i).
|
18057090 |
2008 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
The number of resident CD68+ and CD14+ cells was increased 2-3 fold in the placenta of obese as compared to lean women.
|
18262644 |
2008 |