|
Hodgkin Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Distribution and phenotype of Epstein-Barr virus (EBV)-harboring cells were determined in Hodgkin's disease (HD) biopsies by in situ hybridization with [35S]-labeled RNA probes specific for the small EBV-encoded nuclear RNAs, EBER1 and EBER2, in some instances preceded by immunohistology for CD20, CD30, CD45RO, and CD68 antigens, the T-cell receptor beta-chain, and latent membrane antigen (LMP) of EBV.
|
1320954 |
1992 |
|
Histiocytic sarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We stress the importance of the CD68 marker in the diagnosis of true histiocytic lymphoma, suggest a therapeutic approach based on similarities with monocytic leukemia, and propose the use of the term monocytic sarcoma for this clinicopathological presentation.
|
1471748 |
1992 |
|
Sarcoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We stress the importance of the CD68 marker in the diagnosis of true histiocytic lymphoma, suggest a therapeutic approach based on similarities with monocytic leukemia, and propose the use of the term monocytic sarcoma for this clinicopathological presentation.
|
1471748 |
1992 |
|
Malignant neoplasm of soft tissue
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We stress the importance of the CD68 marker in the diagnosis of true histiocytic lymphoma, suggest a therapeutic approach based on similarities with monocytic leukemia, and propose the use of the term monocytic sarcoma for this clinicopathological presentation.
|
1471748 |
1992 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Although knowledge has accumulated about GP110-CD4 interaction, viral penetration into human CD4+ lymphocytes remains unclear, in spite of the fact that all studies on HIV infection were performed on cell-transformed lineages, or on human polyclonal CD4+ cells.
|
2121340 |
1990 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant.
|
2472638 |
1989 |
|
Epstein-Barr Virus Infections
|
0.050 |
Biomarker
|
group |
BEFREE |
Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant.
|
2472638 |
1989 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Unique immunophenotype of acute promyelocytic leukaemia as defined by CD9 and CD68 antibodies.
|
7803230 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using ISH for EBER combined with immunostaining for CD markers and double immunohistochemistry for LMP and CD markers, the predominant lineage of the EBV+ cells was identified as: CD2+CD3-CD19-CD20- CD45R0 +/- CD56+CD68- in the NK-type cases, CD2+CD3 +/- CD19-CD20- CD45R0+CD56-CD68- in the T-cell case and CD20+CD45R0-CD68- in the B-cell case, in agreement with the genotype and phenotype of each tumour.
|
7829236 |
1995 |
|
Hepatitis A
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of hepatitis A RNA in phagocytic cells was confirmed using immunohistochemistry for a macrophage marker, CD68, combined with in situ hybridization.
|
8014450 |
1994 |
|
IGA Glomerulonephritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The staining patterns and the fact that only very few inflammatory cells, particularly CD68 positive monocytes/macrophages, were detected in glomeruli confirm that predominantly resident glomerular cells (mesangial and endothelial cells) are the major source of up-regulated growth factor production in IgA-GN.
|
8544410 |
1995 |
|
Epstein-Barr Virus Infections
|
0.050 |
Biomarker
|
group |
BEFREE |
To investigate whether gp110, like gB, is essential for EBV infection, a selectable marker was inserted within the gp110 reading frame, BALF4, and the resulting null mutant EBV stain, B95-110HYG, was recovered in lymphoblastoid cell lines (LCLs).
|
8627735 |
1996 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The Epstein-Barr virus (EBV) glycoprotein gp110 has substantial amino acid homology to gB of herpes simplex virus but localizes differently within infected cells and is essentially undetectable in virions.
|
8627735 |
1996 |
|
Asthma
|
0.030 |
Biomarker
|
disease |
BEFREE |
By simultaneous in situ hybridization and immunocytochemistry, IL-10 mRNA was localized to both CD3+ T cells and CD68+ alveolar macrophages in BAL, with a significantly more prominent T-cell signal in the symptomatic asthmatics compared with control subjects and after allergen challenge compared with diluent challenge of the mild asthmatic subjects.
|
8630259 |
1996 |
|
Asthma
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, there was no difference in the number of RANTES-staining cells between normal subjects and asthmatics despite significantly increased numbers of CD4+ T-cells, CD68+ macrophages, and MBP+ eosinophils in mucosal biopsies obtained from asthmatics.
|
8970374 |
1996 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Arterial and arteriolar amyloid-beta (A beta) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using A beta, a-smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry.
|
9056541 |
1997 |
|
Cerebral Amyloid Angiopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Arterial and arteriolar amyloid-beta (A beta) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using A beta, a-smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry.
|
9056541 |
1997 |
|
Familial Cerebral Amyloid Angiopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Arterial and arteriolar amyloid-beta (A beta) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using A beta, a-smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry.
|
9056541 |
1997 |
|
Cerebral Amyloid Angiopathy, Hereditary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Arterial and arteriolar amyloid-beta (A beta) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using A beta, a-smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry.
|
9056541 |
1997 |
|
AURAL ATRESIA, CONGENITAL
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Arterial and arteriolar amyloid-beta (A beta) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using A beta, a-smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry.
|
9056541 |
1997 |
|
Angiomyolipoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Despite the marked morphologic resemblance of these tumors to high-grade sarcomatoid renal cell carcinoma, their phenotype (HMB45+, CD68+/-, actin+/-, and vimentin and keratin negative) is in contrast to that observed in epithelial tumors and parallels the phenotypic profile of angiomyolipoma.
|
9630173 |
1998 |
|
Angiomyolipoma of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
Despite the marked morphologic resemblance of these tumors to high-grade sarcomatoid renal cell carcinoma, their phenotype (HMB45+, CD68+/-, actin+/-, and vimentin and keratin negative) is in contrast to that observed in epithelial tumors and parallels the phenotypic profile of angiomyolipoma.
|
9630173 |
1998 |
|
Epithelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Despite the marked morphologic resemblance of these tumors to high-grade sarcomatoid renal cell carcinoma, their phenotype (HMB45+, CD68+/-, actin+/-, and vimentin and keratin negative) is in contrast to that observed in epithelial tumors and parallels the phenotypic profile of angiomyolipoma.
|
9630173 |
1998 |
|
Gastrointestinal Carcinoid Tumor
|
0.040 |
Biomarker
|
disease |
BEFREE |
Conditioned media from GCT cultures promoted the chemotactic migration of CD68+ peripheral monocytes, an activity which was abolished by the addition of MCP-1 antibody to the conditioned medium.
|
9632113 |
1998 |
|
Giant Cell Tumors
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: possible involvement in CD68+ macrophage-like cell migration.
|
9632113 |
1998 |