Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 GeneticVariation disease BEFREE In 2011, the result of a GWAS revealed a common variant of DEPDC5 affected HCC susceptibility in patient with chronic HCV infection in Japan. 30683632 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 GeneticVariation disease BEFREE Interestingly, these genetic variants also affect the activity of hepatitis, or disease progression in chronic hepatitis C. In addition, polymorphisms in apoptosis-related genes such as RNF7, TULP1, and MERTK are associated with fibrosis progression, and DEPDC5 and MICA variants are associated with HCV-related hepatocellular carcinoma. 26211651 2016
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 GeneticVariation disease BEFREE The aim of the present study was to analyze whether DEPDC5 and MICA genetic variants were associated with liver disease progression in European subjects with chronic HCV infection. 26517016 2016
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 GeneticVariation disease BEFREE Recent studies have associated genetic variation near the interleukin 28B (IL28B/IFN-λ3) gene with natural clearance of the hepatitis C virus (HCV) infection, and a common variant in the DEP domain containing 5 (DEPDC5) locus on chromosome 22 has been shown to affect susceptibility to hepatocellular carcinoma (HCC) in Japanese individuals with chronic HCV infection. 25032264 2014
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 GeneticVariation disease BEFREE Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection. 21725309 2011