HDAC9, histone deacetylase 9, 9734

N. diseases: 340; N. variants: 73
Disease: Spinal Muscular Atrophy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026847
Disease: Spinal Muscular Atrophy
Spinal Muscular Atrophy 		0.030 AlteredExpression disease BEFREE These findings suggest that HDAC inhibitors can potentiate the activity of Nusinersen and support the notion that "SMN-plus" combinatorial therapeutic approaches might represent an enhanced opportunity in the scenario of SMA therapy. 31811660 2019
CUI: C0026847
Disease: Spinal Muscular Atrophy
Spinal Muscular Atrophy 		0.030 Biomarker disease BEFREE Hence, SMN acetylation leads to its dysfunction, which explains the ineffectiveness of HDAC (histone deacetylases) inhibitors in SMA therapy despite their potential to increase SMN levels. 28879433 2018
CUI: C0026847
Disease: Spinal Muscular Atrophy
Spinal Muscular Atrophy 		0.030 Biomarker disease BEFREE Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells. 28648462 2017