|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Because there are no non-synonymous SNPs in TNFSF15, we speculated that one or more of the SNPs associated with CD may act as cis-regulatory SNPs.
|
19124533 |
2009 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies indicate that IL23R and five additional genes involved in Th17 differentiation (IL12B, JAK2, STAT3, CCR6 and TNFSF15) are associated with susceptibility to Crohn's disease and partly also to ulcerative colitis.
|
19592695 |
2009 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
TNFSF15 and ICOSLG-CXCR5 might constitute a shared pathogenic pathway in the development of PBC and CD in the Japanese population, whereas IL12B-STAT4-NFKB1 might constitute an opposite pathogenic pathway, reflecting the different balance between Th1 and Th17 in the two diseases.
|
26084578 |
2015 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
: These results indicate that NOD2 genotype, smoking status, and TNFSF15 genotype should be included as covariates in assessing the effect of genetic and environmental factors on Crohn's disease site location.
|
21730793 |
2011 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To understand the genetic relationship between the two forms of inflammatory bowel disease, we investigated the well-established CD-susceptibility genes TNFSF15 (tumor necrosis factor ligand superfamily, member 15) and IL23R in Korean patients with UC.
|
21228792 |
2011 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The TNFSF15 gene has been associated with other inflammatory diseases affecting the colon such as medically refractory ulcerative colitis (UC), aggressive Crohn's disease (CD), and pouchitis after restorative proctocolectomy.
|
24814505 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility.
|
25028192 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
|
23266558 |
2013 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We observed an association between Crohn's disease (CD) candidate gene TNFSF15 and IBS symptom phenotype.
|
21752155 |
2011 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The SNPs tagging the TNFSF15, NKX2-3, ZNF365, and PTPN2 genes were associated with CD (P values ranging from 0.037 to 7×10(-6)).
|
21818367 |
2011 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among the TNFSF15 SNPs, rs4263839 associated with CD in Taiwan (P = 0.005), haplotype analysis did not increase the association.
|
24783249 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Crohn Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
TL1A expression is increased in inflamed gut mucosa and associated with fibrostenosing Crohn's disease.
|
29988118 |
2018 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate the functional role and therapeutic potential of TL1A/DR3 signaling in Crohn's disease-like ileitis.
|
30295722 |
2019 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Distinct but overlapping TNFSF15 haplotypes were demonstrated in diverticulitis patients versus healthy controls when compared with the known Crohn's risk haplotype suggesting similar but distinct genetic predispositions.
|
28624054 |
2017 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease.
|
16221758 |
2005 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-like cytokine 1A (TL1A) and its receptors, death-domain receptor 3 (DR3) and decoy receptor 3 (DcR3), are mucosal factors with significant involvement in experimental inflammation and CD.
|
27665176 |
2017 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data support the hypothesis that the TNFSF15 genotypes play an important role in the pathogenesis of CD in Koreans.
|
18422820 |
2008 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis.
|
29873318 |
2018 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Our data support the hypothesis that the TNFSF15 genotypes play an important role in the pathogenesis of CD in Koreans.
|
18422820 |
2008 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A total of 906 CD patients having TNFSF15 genotype data and clinical information were recruited from CD registry database of a tertiary referral center.
|
24835165 |
2014 |
|
Crohn Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In summary, we provide evidence that variance within TNFSF15 has the potential to affect cytokine expression across a range of tissues and thereby contribute to protection from infectious diseases such as leprosy, while increasing the risk of immune-mediated diseases including CD and PBC.
|
27507062 |
2016 |