|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate the functional role and therapeutic potential of TL1A/DR3 signaling in Crohn's disease-like ileitis.
|
30295722 |
2019 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nine SNPs located in TNFSF15 on chromosome 9 were related to CD in Han individuals from Southern China.
|
31844038 |
2019 |
|
Crohn Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
TL1A expression is increased in inflamed gut mucosa and associated with fibrostenosing Crohn's disease.
|
29988118 |
2018 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis.
|
29873318 |
2018 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Distinct but overlapping TNFSF15 haplotypes were demonstrated in diverticulitis patients versus healthy controls when compared with the known Crohn's risk haplotype suggesting similar but distinct genetic predispositions.
|
28624054 |
2017 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-like cytokine 1A (TL1A) and its receptors, death-domain receptor 3 (DR3) and decoy receptor 3 (DcR3), are mucosal factors with significant involvement in experimental inflammation and CD.
|
27665176 |
2017 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although our statistical power is limited due to the small sample size, these results support an idea that the genetic susceptibility of TNFSF15 to CD may be confounded, in part, by the increase of Prevotella.
|
28197769 |
2017 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
We investigated T-cell gene expression patterns to determine the mechanisms by which TL1A regulates cytokine production, and whether these associate with outcomes of patients with Crohn's disease (CD).
|
28400196 |
2017 |
|
Crohn Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In summary, we provide evidence that variance within TNFSF15 has the potential to affect cytokine expression across a range of tissues and thereby contribute to protection from infectious diseases such as leprosy, while increasing the risk of immune-mediated diseases including CD and PBC.
|
27507062 |
2016 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Four susceptibility loci, a promoter region in tumor necrosis factor (ligand) superfamily member (TNFSF15) and 3 independent regions in HLAs, showed significant associations with CD.
|
26891255 |
2016 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results confirmed a significant association of CD with the following previously reported risk loci: rs3810936 in TNFSF15 (OR=1.83, p<2.2×10(-16)), rs76418789 in IL23R (OR=0.47, p=1.14×10(-8)) and rs2241880 in ATG16L1 (OR=1.30, p=5.28×10(-6)).
|
25731871 |
2016 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
TNFSF15 and ICOSLG-CXCR5 might constitute a shared pathogenic pathway in the development of PBC and CD in the Japanese population, whereas IL12B-STAT4-NFKB1 might constitute an opposite pathogenic pathway, reflecting the different balance between Th1 and Th17 in the two diseases.
|
26084578 |
2015 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects.
|
26072972 |
2015 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Depending on age categories compared, single nucleotide polymorphisms in POU5F1, TNFSF15, and HLA DRB1*501 were associated with age of Crohn's disease diagnosis.
|
25664710 |
2015 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The TNFSF15 gene has been associated with other inflammatory diseases affecting the colon such as medically refractory ulcerative colitis (UC), aggressive Crohn's disease (CD), and pouchitis after restorative proctocolectomy.
|
24814505 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility.
|
25028192 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among the TNFSF15 SNPs, rs4263839 associated with CD in Taiwan (P = 0.005), haplotype analysis did not increase the association.
|
24783249 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A total of 906 CD patients having TNFSF15 genotype data and clinical information were recruited from CD registry database of a tertiary referral center.
|
24835165 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To date, only one gene (TNFSF15) has been identified and validated as a Crohn's disease (CD)-associated gene in non-Caucasian populations.
|
24945726 |
2014 |
|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Moreover, we found individual disease risk loci: TNFSF15 and TNFα to CD and HLA-B*5201, and NFKBIL1 to UC.
|
23942620 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We examined the association of seven single nucleotide polymorphisms (SNP) in the TNFSF15 gene with Crohn's disease (CD) and ulcerative colitis (UC) in the Indian population.
|
25501099 |
2014 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
|
23266558 |
2013 |
|
Crohn Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IBS-D and PI-IBS patients are associated with TNFSF15 and TNFα genetic polymorphisms which also predispose to Crohn's disease suggesting possible common underlying pathogenesis.
|
22684480 |
2013 |