GPC6, glypican 6, 10082

N. diseases: 86; N. variants: 15
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs143258881
rs143258881
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0002395
Disease:
Alzheimer's Disease 		0.800 GeneticVariation GWASDB Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. 23535033 2014
dbSNP: rs143258881
rs143258881
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0002395
Disease:
Alzheimer's Disease 		0.800 GeneticVariation GWASCAT Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. 23535033 2014
dbSNP: rs9301951
rs9301951
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0158266
Disease:
Intervertebral Disc Degeneration 		C 0.800 GeneticVariation GWASDB Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. 22993228 2013
dbSNP: rs9301951
rs9301951
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0158266
Disease:
Intervertebral Disc Degeneration 		C 0.800 GeneticVariation GWASCAT Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. 22993228 2013
dbSNP: rs7995215
rs7995215
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1263846
Disease:
Attention deficit hyperactivity disorder 		0.800 GeneticVariation GWASDB Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. 18839057 2008
dbSNP: rs7995215
rs7995215
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1263846
Disease:
Attention deficit hyperactivity disorder 		0.800 GeneticVariation GWASCAT Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. 18839057 2008
dbSNP: rs12430764
rs12430764
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0205682
Disease:
Waist-Hip Ratio 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs1328369
rs1328369
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0205682
Disease:
Waist-Hip Ratio 		T 0.700 GeneticVariation GWASCAT Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors. 30575882 2018
dbSNP: rs9584154
rs9584154
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0036341
Disease:
Schizophrenia 		A 0.700 GeneticVariation GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
dbSNP: rs7985891
rs7985891
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1836233
Disease:
AIDS, PROGRESSION TO 		0.700 GeneticVariation GWASCAT Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. 24554482 2014
dbSNP: rs7985891
rs7985891
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0442874
Disease:
Neuropathy 		0.700 GeneticVariation GWASCAT Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. 24554482 2014
dbSNP: rs7985891
rs7985891
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1836230
Disease:
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO 		0.700 GeneticVariation GWASCAT Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. 24554482 2014
dbSNP: rs7985891
rs7985891
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1836231
Disease:
HIV-1, RESISTANCE TO 		0.700 GeneticVariation GWASCAT Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. 24554482 2014
dbSNP: rs7985891
rs7985891
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1836232
Disease:
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO 		0.700 GeneticVariation GWASCAT Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. 24554482 2014
dbSNP: rs2150127
rs2150127
Entrez Id: 10082;100873973
Gene Symbol: GPC6;GPC6-AS2
GPC6;GPC6-AS2
CUI: C0038663
Disease:
Suicide attempt 		0.700 GeneticVariation GWASDB A genome-wide association study of attempted suicide. 21423239 2012
dbSNP: rs7998314
rs7998314
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0162701
Disease:
Polysomnography 		A 0.700 GeneticVariation GWASDB Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. 23251661 2012
dbSNP: rs9524298
rs9524298
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0021655
Disease:
Insulin Resistance 		0.700 GeneticVariation GWASDB Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. 22791750 2012
dbSNP: rs9584224
rs9584224
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs9584224
rs9584224
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs9561329
rs9561329
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1842981
Disease:
NEUROTICISM 		0.700 GeneticVariation GWASDB A genome-wide association study of neuroticism in a population-based sample. 20634892 2010
dbSNP: rs9561329
rs9561329
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0027932
Disease:
Neurotic Disorders 		0.700 GeneticVariation GWASCAT A genome-wide association study of neuroticism in a population-based sample. 20634892 2010
dbSNP: rs121908440
rs121908440
Entrez Id: 10082;100873973
Gene Symbol: GPC6;GPC6-AS2
GPC6;GPC6-AS2
CUI: C1850318
Disease:
Omodysplasia type 1 		T 0.700 CausalMutation CLINVAR
dbSNP: rs863223282
rs863223282
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C1850318
Disease:
Omodysplasia type 1 		G 0.700 CausalMutation CLINVAR
dbSNP: rs17702471
rs17702471
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.010 GeneticVariation BEFREE In the larger dataset, GPC6/GPC5 rs17702471 was associated with the endometrioid subtype among Caucasians (odds ratio (OR) = 1.16, 95% CI = 1.07-1.25, P = 0.0003, FDR = 0.19), whereas F8 rs7053448 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), F8 rs7058826 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), and CAPN13 rs1983383 (OR = 0.79, 95% CI = 0.69-0.90, P = 0.0005, FDR = 0.12) were associated with combined invasive EOC among Asians. 26399219 2015
dbSNP: rs17702471
rs17702471
Entrez Id: 10082
Gene Symbol: GPC6
GPC6
CUI: C0677886
Disease:
Epithelial ovarian cancer 		0.010 GeneticVariation BEFREE In the larger dataset, GPC6/GPC5 rs17702471 was associated with the endometrioid subtype among Caucasians (odds ratio (OR) = 1.16, 95% CI = 1.07-1.25, P = 0.0003, FDR = 0.19), whereas F8 rs7053448 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), F8 rs7058826 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), and CAPN13 rs1983383 (OR = 0.79, 95% CI = 0.69-0.90, P = 0.0005, FDR = 0.12) were associated with combined invasive EOC among Asians. 26399219 2015