CERT1, ceramide transporter 1, 10087

N. diseases: 71; N. variants: 19
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs181686584
rs181686584
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C1629609
Disease:
Age at menopause 		0.700 GeneticVariation GWASDB Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. 23424626 2013
dbSNP: rs200174418
rs200174418
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0001948
Disease:
Alcohol consumption 		0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs12916
rs12916
Entrez Id: 3156;10087
Gene Symbol: HMGCR;CERT1
HMGCR;CERT1
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal 		0.010 GeneticVariation BEFREE The LDL-C-reducing allele of rs12916 in HMGCR was associated with AAA risk (OR, 0.93; 95% CI, 0.89-0.98; P = .009). 29188294 2018
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0004238
Disease:
Atrial Fibrillation 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs4704220
rs4704220
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0005893
Disease:
Body mass index procedure 		0.700 GeneticVariation GWASDB Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. 23001569 2013
dbSNP: rs12916
rs12916
Entrez Id: 3156;10087
Gene Symbol: HMGCR;CERT1
HMGCR;CERT1
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE For the HMGCR rs12916 per LDLC-lowering T-allele, the OR was 1.09 (95% CI: 1.01-1.18) for prostate cancer and 0.89 (95% CI: 0.82-0.96) for breast cancer. 29165714 2018
dbSNP: rs5744533
rs5744533
Entrez Id: 10087;51426
Gene Symbol: CERT1;POLK
CERT1;POLK
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE In this study, we aimed to evaluate the effects of POLK polymorphisms on BC risk.We used the Sequenom MassARRAY method to genotype 3 single nucleotide polymorphisms (SNPs) in POLK (rs3213801, rs10077427, and rs5744533), in order to determine the genotypes of 560 BC patients and 583 controls. 26765445 2016
dbSNP: rs5744533
rs5744533
Entrez Id: 10087;51426
Gene Symbol: CERT1;POLK
CERT1;POLK
CUI: C0684249
Disease:
Carcinoma of lung 		0.010 GeneticVariation BEFREE Haplotype analysis showed that subjects with the POLκ C-G (rs5744533-rs5744724) haplotype had decreased risk of lung cancer (OR=0.69, 95% CI: 0.49-0.98), comparing with those carrying the C-C haplotype. 24012694 2013
dbSNP: rs12916
rs12916
Entrez Id: 3156;10087
Gene Symbol: HMGCR;CERT1
HMGCR;CERT1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0038454
Disease:
Cerebrovascular accident 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs3846663
rs3846663
Entrez Id: 3156;10087
Gene Symbol: HMGCR;CERT1
HMGCR;CERT1
CUI: C0010068
Disease:
Coronary heart disease 		0.700 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0010068
Disease:
Coronary heart disease 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0011847
Disease:
Diabetes 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs17238540
rs17238540
Entrez Id: 3156;10087
Gene Symbol: HMGCR;CERT1
HMGCR;CERT1
CUI: C0011847
Disease:
Diabetes 		0.010 GeneticVariation BEFREE We evaluated the association of a single nucleotide polymorphism (rs17238540) in the HMGCR gene with lipid-lowering response to statins in a large population-based cohort of patients with diabetes. 18815589 2008
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0011849
Disease:
Diabetes Mellitus 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs17238540
rs17238540
Entrez Id: 3156;10087
Gene Symbol: HMGCR;CERT1
HMGCR;CERT1
CUI: C0011849
Disease:
Diabetes Mellitus 		0.010 GeneticVariation BEFREE We evaluated the association of a single nucleotide polymorphism (rs17238540) in the HMGCR gene with lipid-lowering response to statins in a large population-based cohort of patients with diabetes. 18815589 2008
dbSNP: rs12916
rs12916
Entrez Id: 3156;10087
Gene Symbol: HMGCR;CERT1
HMGCR;CERT1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE The rs17238484-G allele seemed to be associated with higher risk of type 2 diabetes (odds ratio [OR] per allele 1·02, 95% CI 1·00-1·05); the rs12916-T allele association was consistent (1·06, 1·03-1·09). 25262344 2015
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0428883
Disease:
Diastolic blood pressure 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0495706
Disease:
elevated blood glucose level 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs4704220
rs4704220
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0578022
Disease:
Finding of body mass index 		0.700 GeneticVariation GWASDB Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. 23001569 2013
dbSNP: rs5744533
rs5744533
Entrez Id: 10087;51426
Gene Symbol: CERT1;POLK
CERT1;POLK
CUI: C0017638
Disease:
Glioma 		0.010 GeneticVariation BEFREE Overall, our results indicated that POLK variants rs3213801 and rs5744533 are not associated with glioma risk and prognosis. 31595696 2019
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0337438
Disease:
Glucose measurement 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0018801
Disease:
Heart failure 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs4704221
rs4704221
Entrez Id: 10087
Gene Symbol: CERT1
CERT1
CUI: C0018935
Disease:
Hematocrit procedure 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016