|
rs12916
|
HMGCR;CERT1
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs12916-T variant in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was inversely associated with prostate cancer (OR: 0.97; 95% CI: 0.94, 1.00; P = 0.03).
|
26992435 |
2016 |
|
rs12916
|
HMGCR;CERT1
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation |
BEFREE |
For the HMGCR rs12916 per LDLC-lowering T-allele, the OR was 1.09 (95% CI: 1.01-1.18) for prostate cancer and 0.89 (95% CI: 0.82-0.96) for breast cancer.
|
29165714 |
2018 |
|
rs12916
|
HMGCR;CERT1
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs12916-T variant in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was inversely associated with prostate cancer (OR: 0.97; 95% CI: 0.94, 1.00; P = 0.03).
|
26992435 |
2016 |
|
rs12916
|
HMGCR;CERT1
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
For the HMGCR rs12916 per LDLC-lowering T-allele, the OR was 1.09 (95% CI: 1.01-1.18) for prostate cancer and 0.89 (95% CI: 0.82-0.96) for breast cancer.
|
29165714 |
2018 |
|
rs12916
|
HMGCR;CERT1
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation |
BEFREE |
The LDL-C-reducing allele of rs12916 in HMGCR was associated with AAA risk (OR, 0.93; 95% CI, 0.89-0.98; P = .009).
|
29188294 |
2018 |
|
rs12916
|
HMGCR;CERT1
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
We also investigated cancer risk for a SNP (rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment.
|
29165714 |
2018 |
|
rs12916
|
HMGCR;CERT1
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
For the HMGCR rs12916 per LDLC-lowering T-allele, the OR was 1.09 (95% CI: 1.01-1.18) for prostate cancer and 0.89 (95% CI: 0.82-0.96) for breast cancer.
|
29165714 |
2018 |
|
rs12916
|
HMGCR;CERT1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs17238484-G allele seemed to be associated with higher risk of type 2 diabetes (odds ratio [OR] per allele 1·02, 95% CI 1·00-1·05); the rs12916-T allele association was consistent (1·06, 1·03-1·09).
|
25262344 |
2015 |
|
rs12916
|
HMGCR;CERT1
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
For the HMGCR rs12916 per LDLC-lowering T-allele, the OR was 1.09 (95% CI: 1.01-1.18) for prostate cancer and 0.89 (95% CI: 0.82-0.96) for breast cancer.
|
29165714 |
2018 |
|
rs12916
|
HMGCR;CERT1
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
We also investigated cancer risk for a SNP (rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment.
|
29165714 |
2018 |
|
rs17238540
|
HMGCR;CERT1
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association of a single nucleotide polymorphism (rs17238540) in the HMGCR gene with lipid-lowering response to statins in a large population-based cohort of patients with diabetes.
|
18815589 |
2008 |
|
rs17238540
|
HMGCR;CERT1
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association of a single nucleotide polymorphism (rs17238540) in the HMGCR gene with lipid-lowering response to statins in a large population-based cohort of patients with diabetes.
|
18815589 |
2008 |
|
rs3846663
|
HMGCR;CERT1
|
Overweight and obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no statistically significant gene-environment interactions were found, people with the haplotype composed of C allele in rs3846662 and T allele in rs3846663 and low frequency of soybean intake had significantly higher risk to overweight and obesity as compared with those with the haplotype consisting of T allele in rs3846662 and C allele in rs3846663 and highly frequent soybean food intake, with an odds ratio of 1.64 (95% confidence interval: 1.15-2.34, P<0.01) after adjusting for the common confounders.
|
24709098 |
2014 |
|
rs3846663
|
HMGCR;CERT1
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study has suggested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake.
|
24709098 |
2014 |
|
rs4629571
|
HMGCR;CERT1
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
No association with PCOS was observed.SNP rs4629571 was associated with increased insulin resistance.
|
19327767 |
2010 |
|
rs4629571
|
HMGCR;CERT1
|
Hyperinsulinism
|
|
0.010 |
GeneticVariation |
BEFREE |
No association with PCOS was observed.SNP rs4629571 was associated with increased insulin resistance.
|
19327767 |
2010 |
|
rs5744533
|
CERT1;POLK
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that subjects with the POLκ C-G (rs5744533-rs5744724) haplotype had decreased risk of lung cancer (OR=0.69, 95% CI: 0.49-0.98), comparing with those carrying the C-C haplotype.
|
24012694 |
2013 |
|
rs5744533
|
CERT1;POLK
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we aimed to evaluate the effects of POLK polymorphisms on BC risk.We used the Sequenom MassARRAY method to genotype 3 single nucleotide polymorphisms (SNPs) in POLK (rs3213801, rs10077427, and rs5744533), in order to determine the genotypes of 560 BC patients and 583 controls.
|
26765445 |
2016 |
|
rs5744533
|
CERT1;POLK
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we aimed to evaluate the effects of POLK polymorphisms on BC risk.We used the Sequenom MassARRAY method to genotype 3 single nucleotide polymorphisms (SNPs) in POLK (rs3213801, rs10077427, and rs5744533), in order to determine the genotypes of 560 BC patients and 583 controls.
|
26765445 |
2016 |
|
rs5744533
|
CERT1;POLK
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that subjects with the POLκ C-G (rs5744533-rs5744724) haplotype had decreased risk of lung cancer (OR=0.69, 95% CI: 0.49-0.98), comparing with those carrying the C-C haplotype.
|
24012694 |
2013 |
|
rs5744533
|
CERT1;POLK
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that subjects with the POLκ C-G (rs5744533-rs5744724) haplotype had decreased risk of lung cancer (OR=0.69, 95% CI: 0.49-0.98), comparing with those carrying the C-C haplotype.
|
24012694 |
2013 |
|
rs5744533
|
CERT1;POLK
|
Glioma
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, our results indicated that POLK variants rs3213801 and rs5744533 are not associated with glioma risk and prognosis.
|
31595696 |
2019 |
|
rs1554048616
|
CERT1;POLK
|
MENTAL RETARDATION, AUTOSOMAL DOMINANT 34
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs12916
|
HMGCR;CERT1
|
Low density lipoprotein cholesterol measurement
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
|
30670697 |
2019 |
|
rs12916
|
HMGCR;CERT1
|
Serum total cholesterol measurement
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |