DisGeNET - a database of gene-disease associations

CHUK, component of inhibitor of nuclear factor kappa B kinase complex, 1147

N. diseases: 125; N. variants: 6

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs17882802

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C1629609
Disease:

Age at menopause

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs11591741

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

30054458

2018

dbSNP:

rs11597086

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs17883880

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C0202117
Disease:

Low density lipoprotein cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs17883880

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C0428474
Disease:

Serum LDL cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs17883880

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C0202236
Disease:

Triglycerides measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs17883880

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs267606736

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C3150891
Disease:

COCOON SYNDROME

0.700

CausalMutation

CLINVAR

dbSNP:

rs2230804

Entrez Id:	1147
Gene Symbol:	CHUK

CHUK

CUI:	C0043144
Disease:

Wheezing

0.010

GeneticVariation

BEFREE

Of the remaining 15 SNPs, for seven we found significant relationships between genotype and endotoxin exposure in the genetic association study in relation to symptomatic airway hyper-responsiveness (CD14-rs2915863 and rs2569191, TRIF-rs4807000), current wheeze (ST-2-rs17639215, IKK-1-rs2230804, and TRIF-rs4807000), and atopy (CD14-rs2915863 and rs2569192, TRAF-6-rs5030411, and IKK-1-rs2230804).

25102764

2014