TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Depressive disorder ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs78162420
rs78162420
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.010 GeneticVariation BEFREE Among patients with PD, depression is associated with polymorphism at rs78162420 and rs1545843, both previously linked with depression. 28320136 2017
dbSNP: rs120074175
rs120074175
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.010 GeneticVariation BEFREE Here we use chronic multicircuit neurophysiological recordings to characterize functional interactions across cortical and limbic circuits in mice engineered to express a human loss-of-function depression allele Tph2-(R441H) [Tph2 knockin (Tph2KI)]. 23467366 2013
dbSNP: rs12229394
rs12229394
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.010 GeneticVariation BEFREE The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men. 19548263 2010
dbSNP: rs7305115
rs7305115
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.020 GeneticVariation BEFREE There was a significant interactive effect of rs7305115 polymorphisms and depression diagnosis on Symbol Digit Modalities Test (SDMT) (P<0.05). 26057341 2015
dbSNP: rs7305115
rs7305115
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.020 GeneticVariation BEFREE We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life. 25214390 2014