|
rs283413
|
ADH1B;ADH1C
|
PARKINSON DISEASE, MITOCHONDRIAL (disorder)
|
A |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs283413
|
ADH1B;ADH1C
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the G78stop mutation was identified in 4 (10.0%) of 40 Caucasian index cases with PD with mainly hereditary forms of the disorder.
|
15642852 |
2005 |
|
rs932546861
|
ADH1B;ADH1C
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the G78stop mutation was identified in 4 (10.0%) of 40 Caucasian index cases with PD with mainly hereditary forms of the disorder.
|
15642852 |
2005 |
|
rs1693482
|
ADH1B;ADH1C
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
There were nonstatistically significant associations between rs693482 C-->T and rs698 A-->G mutations and prevalent CVD among current drinkers (lower CVD prevalence with minor allele) but not among nondrinkers in whom the minor allele was associated with a trend toward higher CVD prevalence (p values for interaction are 0.16 for rs1693482 and 0.52 for rs698).
|
16018848 |
2005 |
|
rs698
|
ADH1B;ADH1C
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
There were nonstatistically significant associations between rs693482 C-->T and rs698 A-->G mutations and prevalent CVD among current drinkers (lower CVD prevalence with minor allele) but not among nondrinkers in whom the minor allele was associated with a trend toward higher CVD prevalence (p values for interaction are 0.16 for rs1693482 and 0.52 for rs698).
|
16018848 |
2005 |
|
rs35385902
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.020 |
GeneticVariation |
BEFREE |
In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism.
|
16086315 |
2005 |
|
rs35385902
|
ADH1B;ADH1C
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Joint effects of eNOS gene T-786C and ADH2 Arg47His polymorphisms on the risk of premature coronary artery disease.
|
17289126 |
2007 |
|
rs35385902
|
ADH1B;ADH1C
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The mutant genotypes of eNOS gene T-786C mutation and the fast form of ADH2 Arg47His polymorphism had an additive interaction on the risk of premature CAD in Chinese population.
|
17289126 |
2007 |
|
rs1693482
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
Numerous SNPs in ADH genes showed association with AD, including one marker in the coding region of ADH1C (rs1693482 in exon6, Ile271Gln).
|
18331377 |
2008 |
|
rs35385902
|
ADH1B;ADH1C
|
Flushing
|
|
0.010 |
GeneticVariation |
BEFREE |
These results bridge the gap between DNA sequence variation and alcohol-related behavior, confirming that the ADH1B-Arg48His polymorphism affects both alcohol-related flushing in Europeans and alcohol intake.
|
18996923 |
2009 |
|
rs35385902
|
ADH1B;ADH1C
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs35385902
|
ADH1B;ADH1C
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation |
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs1693482
|
ADH1B;ADH1C
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs1693482
|
ADH1B;ADH1C
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation |
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs35385902
|
ADH1B;ADH1C
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs35385902
|
ADH1B;ADH1C
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs698
|
ADH1B;ADH1C
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs698
|
ADH1B;ADH1C
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs1693482
|
ADH1B;ADH1C
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them.
|
19861527 |
2009 |
|
rs1693482
|
ADH1B;ADH1C
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them.
|
19861527 |
2009 |
|
rs35385902
|
ADH1B;ADH1C
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg(48)His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21-16.11).
|
19887496 |
2010 |
|
rs35385902
|
ADH1B;ADH1C
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg(48)His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21-16.11).
|
19887496 |
2010 |
|
rs1693482
|
ADH1B;ADH1C
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06).
|
20350778 |
2010 |
|
rs1693482
|
ADH1B;ADH1C
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06).
|
20350778 |
2010 |
|
rs1693482
|
ADH1B;ADH1C
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
The ADH1c (rs1693482) fast metabolizing CC genotype was associated with an increased risk of impaired glucose tolerance (IGT)/diabetes compared to the CT and TT genotypes.
|
20700531 |
2010 |