|
rs1614972
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.710 |
GeneticVariation |
BEFREE |
Despite a number of potential differences between the samples investigated by the prior GWAS and the current study, data presented here provide additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence and extend this finding by demonstrating association with consumption levels in both non-alcoholic and alcohol-dependent populations.
|
23516558 |
2013 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.
|
28610454 |
2018 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms.
|
27172571 |
2016 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected.
|
22325912 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample.
|
25372623 |
2015 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
The results showed strong evidence of association between ADH1C Ile350Val (rs698, formerly ADH1C *1/*2) and alcohol dependence (AD) and abuse in the combined studies.
|
22476623 |
2012 |
|
rs35385902
|
ADH1B;ADH1C
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs35385902
|
ADH1B;ADH1C
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation |
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs35385902
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.020 |
GeneticVariation |
BEFREE |
In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism.
|
16086315 |
2005 |
|
rs35385902
|
ADH1B;ADH1C
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs35385902
|
ADH1B;ADH1C
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs35385902
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.020 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.
|
28610454 |
2018 |
|
rs698
|
ADH1B;ADH1C
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
The results indicate that ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians.
|
22675424 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
The results indicate that ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians.
|
22675424 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
rs141973904
|
ADH1B;ADH1C
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The gene ADH1C, which has been previously implicated in AUD, was among our most significant associations (4.4 × 10<sup>-7</sup> ; rs141973904).
|
29058377 |
2019 |
|
rs1614972
|
ADH1B;ADH1C
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation |
BEFREE |
In the study, we examined the association between five ADH1B-ADH1C-ADH7 cluster SNPs (rs1042026, rs17033, rs1614972, rs1789903 and rs17028973) and risk of developing ESCC.
|
24722735 |
2014 |
|
rs1693482
|
ADH1B;ADH1C
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs1693482
|
ADH1B;ADH1C
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
There were nonstatistically significant associations between rs693482 C-->T and rs698 A-->G mutations and prevalent CVD among current drinkers (lower CVD prevalence with minor allele) but not among nondrinkers in whom the minor allele was associated with a trend toward higher CVD prevalence (p values for interaction are 0.16 for rs1693482 and 0.52 for rs698).
|
16018848 |
2005 |
|
rs1693482
|
ADH1B;ADH1C
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06).
|
20350778 |
2010 |
|
rs1693482
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
Numerous SNPs in ADH genes showed association with AD, including one marker in the coding region of ADH1C (rs1693482 in exon6, Ile271Gln).
|
18331377 |
2008 |
|
rs1693482
|
ADH1B;ADH1C
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them.
|
19861527 |
2009 |
|
rs1693482
|
ADH1B;ADH1C
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them.
|
19861527 |
2009 |
|
rs1693482
|
ADH1B;ADH1C
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
The ADH1c (rs1693482) fast metabolizing CC genotype was associated with an increased risk of impaired glucose tolerance (IGT)/diabetes compared to the CT and TT genotypes.
|
20700531 |
2010 |