|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Essential Hypertension
|
|
0.010 |
GeneticVariation |
BEFREE |
A T1083C polymorphism in the human adenosine A2a receptor gene is not associated with essential hypertension.
|
9880133 |
1998 |
|
rs2236624
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was observed between SNP rs2236624 and PDR in the recessive genetic model.
|
21088442 |
2011 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.
|
20334879 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.040 |
GeneticVariation |
BEFREE |
A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.
|
20334879 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Phobic anxiety disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.
|
20334879 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Familial neurocardiogenic syncope
|
|
0.010 |
GeneticVariation |
BEFREE |
Adenosine A(2A) receptor 1083 T > C polymorphism is not associated with the positivity of HUT and its proposed role in predisposition to VVS was not confirmed.
|
26710963 |
2016 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Leukoencephalopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
ADORA2A rs2298383 and high cumulative dose of systemic MTX administration were significantly associated with MTX-related leukoencephalopathy.
|
27399166 |
2016 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
ADORA2A has been shown to be responsible for the wakefulness-promoting effect of caffeine and the 1976T>C genotype (SNP rs5751876, formerly 1083T>C) to contribute to individual sensitivity to caffeine effects on sleep.
|
31817803 |
2019 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
An association between the ADORA2A rs2298383 TT genotype with the presence of anxiety disorders (P = .004) and an interaction between ADORA2A-DRD2 risk haplotypes with the same outcome (P = .005) was detected.
|
30946941 |
2019 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Headache
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.040 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia.
|
17329997 |
2007 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Sleeplessness
|
|
0.020 |
GeneticVariation |
BEFREE |
Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia.
|
17329997 |
2007 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, it was investigated whether the adenosine 2 A receptor gene (ADORA2A) 1976T/C (rs5751876) variant - previously associated with anxiety disorders and anxiety-related phenotypes as well as general attentional efficiency -was involved in the regulation of this network.
|
27262510 |
2016 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Depressive episode, unspecified
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we examined an association between a single nucleotide polymorphism in A<sub>2A</sub> receptor gene (ADORA2A, rs2298383 SNP) with current depressive episode and symptom profile.
|
30511252 |
2019 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxious personality
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, as rs5751876 is assumed not to be the disease variant itself but to be in linkage disequilibrium (LD) with the true functional polymorphism other SNPs of potentially functional relevance were identified by re-sequencing the whole gene including several newly identified regions of putative regulatory potential and analysed for their impact on PD and anxious personality.
|
20334879 |
2010 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Sleeplessness
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the rs2298383 T and rs4822492 G alleles were associated with higher risk of sleep complaints (Ora = 1.9 [1.2-3.1] and Ora = 1.5 [1.1-2.1]) and insomnia (Ora = 1.5 [1.3-2.5] and Ora = 1.9 [1.3-3.2).
|
31817803 |
2019 |