|
rs4234080
|
METTL21A
|
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
rs4234080
|
METTL21A
|
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
rs4234080
|
METTL21A
|
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
rs4234080
|
METTL21A
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
rs6785
|
CREB1;METTL21A
|
Bronchopulmonary Dysplasia
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we further expanded our analyses of rs2709370 and rs6785 in multiple BPD, SCZ and MDD data sets, including the published Psychiatric Genomics Consortium (PGC) genome-wide association study, the samples used in our previous CREB1 study, and six additional cohorts (three new BPD samples, two new SCZ samples and one new MDD sample).
|
29158582 |
2018 |
|
rs6785
|
CREB1;METTL21A
|
Borderline Personality Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we further expanded our analyses of rs2709370 and rs6785 in multiple BPD, SCZ and MDD data sets, including the published Psychiatric Genomics Consortium (PGC) genome-wide association study, the samples used in our previous CREB1 study, and six additional cohorts (three new BPD samples, two new SCZ samples and one new MDD sample).
|
29158582 |
2018 |
|
rs6785
|
CREB1;METTL21A
|
Schizophrenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts (BPD analysis in 871 cases and 1089 controls (rs2709370, P=0.0611; rs6785, P=0.0544); SCZ analysis in 1273 cases and 1072 controls (rs2709370, P=0.230; rs6785, P=0.661); and MDD analysis in 129 cases and 100 controls (rs2709370, P=0.114; rs6785, P=0.188)), an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 × 10<sup>-4</sup>; rs6785, P=6.33 × 10<sup>-5</sup>), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 × 10<sup>-5</sup>; rs6785, P=2.44 × 10<sup>-5</sup>) and MDD (9369 cases and 9619 controls; rs2709370, P=0.0144; rs6785, P=0.0314), with the same direction of allelic effects across diagnostic categories.
|
29158582 |
2018 |
|
rs6785
|
CREB1;METTL21A
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts (BPD analysis in 871 cases and 1089 controls (rs2709370, P=0.0611; rs6785, P=0.0544); SCZ analysis in 1273 cases and 1072 controls (rs2709370, P=0.230; rs6785, P=0.661); and MDD analysis in 129 cases and 100 controls (rs2709370, P=0.114; rs6785, P=0.188)), an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 × 10<sup>-4</sup>; rs6785, P=6.33 × 10<sup>-5</sup>), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 × 10<sup>-5</sup>; rs6785, P=2.44 × 10<sup>-5</sup>) and MDD (9369 cases and 9619 controls; rs2709370, P=0.0144; rs6785, P=0.0314), with the same direction of allelic effects across diagnostic categories.
|
29158582 |
2018 |
|
rs2551941
|
METTL21A
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events.
|
28225778 |
2017 |
|
rs2551941
|
METTL21A
|
Unipolar Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events.
|
28225778 |
2017 |