ADRB1, adrenoceptor beta 1, 153

N. diseases: 130; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005612
Disease:
Birth Weight 		C 0.800 GeneticVariation GWASCAT Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. 31043758 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005612
Disease:
Birth Weight 		G 0.800 GeneticVariation GWASCAT New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. 23202124 2013
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005612
Disease:
Birth Weight 		G 0.800 GeneticVariation GWASDB New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. 23202124 2013
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.740 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.740 GeneticVariation BEFREE We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. 24982877 2014
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.740 GeneticVariation BEFREE The Arg389Gly polymorphism of the ADRB1 gene may be a worthy biological marker to predict the risk of developing cardiovascular diseases given a high-risk atherogenic index. 24371822 2013
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.740 GeneticVariation BEFREE Various studies suggest an association between beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and cardiovascular disorders, including hypertension, cardiomyopathy and congestive heart failure.2. 19673943 2009
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.740 GeneticVariation BEFREE The human beta(1)-adrenergic receptor, an important therapeutic target in cardiovascular diseases, has 2 common functional polymorphisms (Ser49Gly and Gly389Arg). 16815314 2006
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0428883
Disease:
Diastolic blood pressure 		G 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure 		C 0.700 GeneticVariation GWASCAT Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. 27618447 2016
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure 		G 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure 		G 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0428883
Disease:
Diastolic blood pressure 		C 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C1305849
Disease:
Diastolic blood pressure measurement 		C 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0428883
Disease:
Diastolic blood pressure 		0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease:
Congestive heart failure 		0.100 GeneticVariation BEFREE We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients. 21395649 2011
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure 		0.100 GeneticVariation BEFREE One study of risk for heart failure suggested a synergistic effect of ADRB1 Arg389Gly with the insertion/deletion polymorphism in the alpha2C-adrenergic receptor gene (ADRA2C). 17496726 2007
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure 		0.100 GeneticVariation BEFREE Since the pivotal role of β1 adrenergic receptor (β1-AR) in HF, many publications have studied the associations between the β1-AR polymorphisms (Ser49Gly and Arg389Gly) and HF, with inconsistent results. 22815685 2012
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure 		0.100 GeneticVariation BEFREE An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. 12921807 2003
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease:
Congestive heart failure 		0.100 GeneticVariation BEFREE The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 23065660 2013
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease:
Congestive heart failure 		0.100 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607 2005
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure 		0.100 GeneticVariation BEFREE The Arg389Gly polymorphism has a major impact on the heart-rate response to carvedilol (but not bisoprolol) in patients with heart failure plus atrial fibrillation. 22617224 2012
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure 		0.100 GeneticVariation BEFREE The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity. 30978507 2019