DPYD, dihydropyrimidine dehydrogenase, 1806

N. diseases: 249; N. variants: 101
Disease: Sickle Cell Dactylitis ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12022243
rs12022243
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
CUI: C0852711
Disease:
Sickle Cell Dactylitis 		0.010 GeneticVariation BEFREE We identified the first common DPYD polymorphisms to be consistently associated with capecitabine toxicity, rs12132152 (toxicity allele frequency (TAF)=0.031, OR=3.83, p=4.31×10(-6)) and rs12022243 (TAF=0.196, OR=1.69, p=2.55×10(-5)). rs12132152 was particularly strongly associated with hand-foot syndrome (OR=6.1, p=3.6×10(-8)). 24647007 2015
dbSNP: rs7548189
rs7548189
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
CUI: C0852711
Disease:
Sickle Cell Dactylitis 		0.010 GeneticVariation BEFREE A candidate gene study of capecitabine-related toxicity reported that the s12132152 were strongly associated with hand-foot syndrome (HFS), whereas rs7548189 was associated with diarrhea. 25800061 2015