DUSP6, dual specificity phosphatase 6, 1848

N. diseases: 196; N. variants: 5
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs139318648
rs139318648
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease:
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		0.800 GeneticVariation UNIPROT Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. 23643382 2013
dbSNP: rs146089505
rs146089505
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease:
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		0.800 GeneticVariation UNIPROT Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. 23643382 2013
dbSNP: rs139318648
rs139318648
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease:
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		A 0.800 SusceptibilityMutation CLINVAR
dbSNP: rs146089505
rs146089505
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease:
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		A 0.800 SusceptibilityMutation CLINVAR
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0596887
Disease:
mathematical ability 		C 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0596887
Disease:
mathematical ability 		A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs143946794
rs143946794
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease:
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		C 0.700 CausalMutation CLINVAR
dbSNP: rs587776978
rs587776978
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease:
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		T 0.700 CausalMutation CLINVAR
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.020 GeneticVariation BEFREE Individuals are carrying DUSP6 rs2279574 AA and AC genotypes associated with an increased risk in developing lung squamous carcinoma in Han Chinese and with advanced NSCLC stages. 29578153 2018
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.020 GeneticVariation BEFREE CONCLUSIONS TOP2A rs471692 and DUSP6 rs2279574 SNPs were not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with NSCLC. 28231233 2017
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0001418
Disease:
Adenocarcinoma 		0.010 GeneticVariation BEFREE Individuals are carrying DUSP6 rs2279574 AA and AC genotypes associated with an increased risk in developing lung squamous carcinoma in Han Chinese and with advanced NSCLC stages. 29578153 2018
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0684249
Disease:
Carcinoma of lung 		0.010 GeneticVariation BEFREE Moreover, DUSP6 rs2279574 AA genotype was also significantly associated with advanced stages of lung cancer. 29578153 2018
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C1306460
Disease:
Primary malignant neoplasm of lung 		0.010 GeneticVariation BEFREE Moreover, DUSP6 rs2279574 AA genotype was also significantly associated with advanced stages of lung cancer. 29578153 2018
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0242379
Disease:
Malignant neoplasm of lung 		0.010 GeneticVariation BEFREE Moreover, DUSP6 rs2279574 AA genotype was also significantly associated with advanced stages of lung cancer. 29578153 2018
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE CONCLUSIONS TOP2A rs471692 and DUSP6 rs2279574 SNPs were not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with NSCLC. 28231233 2017
dbSNP: rs2279574
rs2279574
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease:
Bipolar Disorder 		0.010 GeneticVariation BEFREE Previously, we reported a positive association between the functional Leu114Val polymorphism (rs2279574) in DUSP6 and bipolar disorder. 22155192 2012