FN1, fibronectin 1, 2335

N. diseases: 724; N. variants: 33
Disease: Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1418810723
rs1418810723
Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0027651
Disease:
Neoplasms 		0.030 GeneticVariation BEFREE In particular, FN1 mRNA levels were higher in tumor vs non-tumor tissue (117.3, p < 0.001) and also in aggressive and BRAF(V600E) samples. 27173027 2016
dbSNP: rs1418810723
rs1418810723
Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0027651
Disease:
Neoplasms 		0.030 GeneticVariation BEFREE Patients with PTC harboring the BRAF(V600E) mutation seem to display a more aggressive clinical behavior, but little is known about the role of this mutation in crucial processes in the tumor microenvironment, such as tumor adhesion, migration, invasion, and metastasis. 21447745 2011
dbSNP: rs1418810723
rs1418810723
Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0027651
Disease:
Neoplasms 		0.030 GeneticVariation BEFREE Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway. 16960555 2007
dbSNP: rs6707530
rs6707530
Entrez Id: 2335;112268430
Gene Symbol: FN1;LOC112268430
FN1;LOC112268430
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE SNP analysis indicated that 44 tumors with a GG genotype at SNP rs6707530 showed significantly higher FN1 expression than did 23 tumors with GT/TT genotypes (p<0.05). 24919860 2014