ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Disease: Adenocarcinoma of lung (disorder) ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519781
rs1057519781
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		G 0.700 GeneticVariation CLINVAR Ceritinib in ALK-rearranged non-small-cell lung cancer. 24670165 2014
dbSNP: rs1057519782
rs1057519782
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Ceritinib in ALK-rearranged non-small-cell lung cancer. 24670165 2014
dbSNP: rs1057519784
rs1057519784
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Furthermore, HSP90 inhibition, as well as the second-generation ALK inhibitor TAE684, demonstrated activity in newly developed lung adenocarcinoma models driven by crizotinib-insensitive EML4-ALK L1196M or F1174L. 24327273 2014
dbSNP: rs1057519784
rs1057519784
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Ceritinib in ALK-rearranged non-small-cell lung cancer. 24670165 2014
dbSNP: rs863225281
rs863225281
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		C 0.700 GeneticVariation CLINVAR Furthermore, HSP90 inhibition, as well as the second-generation ALK inhibitor TAE684, demonstrated activity in newly developed lung adenocarcinoma models driven by crizotinib-insensitive EML4-ALK L1196M or F1174L. 24327273 2014
dbSNP: rs863225281
rs863225281
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Furthermore, HSP90 inhibition, as well as the second-generation ALK inhibitor TAE684, demonstrated activity in newly developed lung adenocarcinoma models driven by crizotinib-insensitive EML4-ALK L1196M or F1174L. 24327273 2014
dbSNP: rs1057519781
rs1057519781
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		G 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784 2012
dbSNP: rs1057519782
rs1057519782
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784 2012
dbSNP: rs1057519783
rs1057519783
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784 2012
dbSNP: rs1057519784
rs1057519784
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784 2012
dbSNP: rs1057519785
rs1057519785
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		C 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784 2012
dbSNP: rs863225281
rs863225281
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		C 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784 2012
dbSNP: rs863225281
rs863225281
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784 2012
dbSNP: rs779318085
rs779318085
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		0.010 GeneticVariation BEFREE Detection of PIK3CA mutations, including a novel mutation of V344G in exon 4, in metastatic lung adenocarcinomas: A retrospective study of 115 FNA cases. 27007084 2016