DisGeNET - a database of gene-disease associations

GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23

Disease: Serum total cholesterol measurement ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetic analyses of diverse populations improves discovery for complex traits.

31217584

2019

dbSNP:

rs780093

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetic analyses of diverse populations improves discovery for complex traits.

31217584

2019

dbSNP:

rs780094

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetic analyses of diverse populations improves discovery for complex traits.

31217584

2019

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

A large electronic-health-record-based genome-wide study of serum lipids.

29507422

2018

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

29403010

2018

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

30275531

2018

dbSNP:

rs780093

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

A large electronic-health-record-based genome-wide study of serum lipids.

29507422

2018

dbSNP:

rs780094

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.

29615537

2018

dbSNP:

rs780092

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

28334899

2017

dbSNP:

rs780093

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

28334899

2017

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

27286809

2016

dbSNP:

rs780094

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

27790247

2016

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

The impact of low-frequency and rare variants on lipid levels.

25961943

2015

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Discovery and refinement of loci associated with lipid levels.

24097068

2013

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

Discovery and refinement of loci associated with lipid levels.

24097068

2013

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

A genome wide association study identifies common variants associated with lipid levels in the Chinese population.

24386095

2013

dbSNP:

rs780092

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.

24023260

2013

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs780093

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs780094

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Biological, clinical and population relevance of 95 loci for blood lipids.

20686565

2010

dbSNP:

rs1260326

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

Biological, clinical and population relevance of 95 loci for blood lipids.

20686565

2010

dbSNP:

rs780090

Entrez Id:	2646;64838
Gene Symbol:	GCKR;FNDC4

GCKR;FNDC4

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs814295

Entrez Id:	2646
Gene Symbol:	GCKR

GCKR

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012