GLP1R, glucagon like peptide 1 receptor, 2740

N. diseases: 288; N. variants: 7
Disease: Diabetes Mellitus, Non-Insulin-Dependent ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9394574
rs9394574
Entrez Id: 2740
Gene Symbol: GLP1R
GLP1R
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.700 GeneticVariation GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
dbSNP: rs367543060
rs367543060
Entrez Id: 2740
Gene Symbol: GLP1R
GLP1R
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 GeneticVariation BEFREE Yet, there was no significant association of GIPR rs1800437 or GLP-1R rs367543060 with T2DM risk. 28744963 2017
dbSNP: rs367543060
rs367543060
Entrez Id: 2740
Gene Symbol: GLP1R
GLP1R
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 GeneticVariation BEFREE A genetic link between the T149M variant and increased susceptibility to type 2 diabetes remains to be established. 15975668 2005
dbSNP: rs10305420
rs10305420
Entrez Id: 2740
Gene Symbol: GLP1R
GLP1R
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE The consistent large clinical impact of rs10305420 on glycemic response and weight response to exenatide makes the variant a strong candidate biomarker for precision medicine, particularly among overweight patients with Type 2 diabetes. 30883264 2019
dbSNP: rs10305492
rs10305492
Entrez Id: 2740;105375046
Gene Symbol: GLP1R;LOC105375046
GLP1R;LOC105375046
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE A low-frequency missense variant (Ala316Thr; rs10305492) in the gene encoding glucagon-like peptide-1 receptor (GLP1R), the target of GLP1R agonists, was associated with lower fasting glucose and T2D risk, consistent with GLP1R agonist therapies. 27252175 2016
dbSNP: rs3765467
rs3765467
Entrez Id: 2740
Gene Symbol: GLP1R
GLP1R
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE We aimed to investigate whether genetic variations in glucagon-like peptide (GLP-1) receptor are associated with responses to DPP-4 inhibitors in patients with type 2 diabetes.Genetic variations of rs3765467 in GLP-1 receptor were explored in 246 patients with type 2 diabetes who received DPP-4 inhibitors treatment for 24 weeks in addition to previous medication. 27858848 2016
dbSNP: rs6923761
rs6923761
Entrez Id: 2740
Gene Symbol: GLP1R
GLP1R
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE Our cross-sectional study revealed an association between the rs6923761 GLP-1 receptor polymorphism (A allele carriers) and basal GLP-1 levels in naïve patients with diabetes mellitus type 2. 25200998 2015