Gene polymorphisms: <i>SOD2</i> rs4880, <i>SOD3</i> rs2536512 and rs2855262, <i>GPX</i> rs3828599, and <i>GSTT1</i> (deletion) were evaluated the associations with HTG, low HDL-C, high TG/HDL-C ratio, and severity of coronary atherosclerosis.
Gene polymorphisms: <i>SOD2</i> rs4880, <i>SOD3</i> rs2536512 and rs2855262, <i>GPX</i> rs3828599, and <i>GSTT1</i> (deletion) were evaluated the associations with HTG, low HDL-C, high TG/HDL-C ratio, and severity of coronary atherosclerosis.
As the result, the AG genotype of rs3805435had an adjusted odds ratio (OR) of 0.54 (95% confidence interval = 0.37-0.79, p = 0.001) compared with the AA genotype in the SSNHL cases.
By using the LRMW method, three variants (fetal rs625879, maternal rs2169650, and maternal rs8177441) were identified with a joint association to CHD risk (nominal P-value = 1.13e-07).
This study shows that serum levels of GPx3 are increased in subjects with MetS and that rs8177409 SNP was associated with cardiovascular risk in a Mexican population.
Four SNPs (GPX3 rs2070593, rsGPX4 rs2074451, SELS rs9874, and TXNRD1 rs17202060) significantly interacted with dietary oxidative balance score after adjustment for multiple comparisons to alter breast cancer risk.
Four SNPs (GPX3 rs2070593, rsGPX4 rs2074451, SELS rs9874, and TXNRD1 rs17202060) significantly interacted with dietary oxidative balance score after adjustment for multiple comparisons to alter breast cancer risk.
In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH).
In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH).
The aim of the present investigation was to test whether functional single nucleotide polymorphisms (SNPs) in genes involved in the generation of NADPH-dependent O₂•⁻ (-675 T → A in CYBA, unregistered) and in glutathione metabolism (-129 C → T in GCLC [rs17883901] and -65 T → C in GPX3 [rs8177412]) confer susceptibility to renal disease in type 1 diabetes patients.
Single-point analysis revealed that the G allele of htSNP rs8177412 was significantly overtransmitted to affected AS children (T/U = 25 : 11, χ(2) = 5.54, P = 0.019), but not to affected TS children (T/U = 49 : 40, χ(2) = 0.91, P = 0.34).
The aim of the present investigation was to test whether functional single nucleotide polymorphisms (SNPs) in genes involved in the generation of NADPH-dependent O₂•⁻ (-675 T → A in CYBA, unregistered) and in glutathione metabolism (-129 C → T in GCLC [rs17883901] and -65 T → C in GPX3 [rs8177412]) confer susceptibility to renal disease in type 1 diabetes patients.
A total of 6 tSNPs (rs3763013, rs8177412, rs3805435, rs3828599, rs3792796, and rs2070593) of GPX3 were genotyped in Chinese DTC cases (n = 268) and controls (n = 378).
A total of 6 tSNPs (rs3763013, rs8177412, rs3805435, rs3828599, rs3792796, and rs2070593) of GPX3 were genotyped in Chinese DTC cases (n = 268) and controls (n = 378).
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.