|
rs115929572
|
GSTM1;GSTM2
|
Blood Protein Measurement
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
rs768623239
|
GSTM1;GSTM2
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
We investigated whether GSTT1 ("null" allele), GSTM1 ("null"allele), GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast cancer (EBC) treated with adjuvant chemotherapy (CT).
|
28747156 |
2017 |
|
rs768623239
|
GSTM1;GSTM2
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
We investigated whether GSTT1 ("null" allele), GSTM1 ("null"allele), GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast cancer (EBC) treated with adjuvant chemotherapy (CT).
|
28747156 |
2017 |
|
rs768623239
|
GSTM1;GSTM2
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity.
|
20670164 |
2010 |
|
rs768623239
|
GSTM1;GSTM2
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity.
|
20670164 |
2010 |
|
rs768623239
|
GSTM1;GSTM2
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing.
|
17180579 |
2007 |
|
rs768623239
|
GSTM1;GSTM2
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing.
|
17180579 |
2007 |
|
rs768623239
|
GSTM1;GSTM2
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
Trends in the association between urinary ITC and breast cancer were more consistent with homozygous deletion of GSTM1 or GSTT1, the AAgenotype of GSTP1 (A313G), or with the C allele of NADPH quinine oxidoreductase (C609T), although interactions were not statistically significant.
|
12873994 |
2003 |
|
rs768623239
|
GSTM1;GSTM2
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
Trends in the association between urinary ITC and breast cancer were more consistent with homozygous deletion of GSTM1 or GSTT1, the AAgenotype of GSTP1 (A313G), or with the C allele of NADPH quinine oxidoreductase (C609T), although interactions were not statistically significant.
|
12873994 |
2003 |
|
rs536289169
|
GSTM1;GSTM2
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs536289169
|
GSTM1;GSTM2
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs536289169
|
GSTM1;GSTM2
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs536289169
|
GSTM1;GSTM2
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
To evaluate whether the genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1), Ile105Val of the GSTP1 (rs947894), and the Val16Ala polymorphism of the MnSOD (rs4880) are associated with essential arterial hypertension (EAH) in Caucasians with type 2 diabetes.
|
24685594 |
2014 |
|
rs768623239
|
GSTM1;GSTM2
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
Combination of the high-risk genotypes (GSTM1 null + GSTT1 null + GSTP1 313 A/G or G/G) demonstrated further increase in the BC risk (OR = 6.64, 95 %CI = 3.63-12.16).
|
23054023 |
2013 |
|
rs768623239
|
GSTM1;GSTM2
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation |
BEFREE |
Combination of the high-risk genotypes (GSTM1 null + GSTT1 null + GSTP1 313 A/G or G/G) demonstrated further increase in the BC risk (OR = 6.64, 95 %CI = 3.63-12.16).
|
23054023 |
2013 |
|
rs768623239
|
GSTM1;GSTM2
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation |
BEFREE |
Combination of the high-risk genotypes (GSTM1 null + GSTT1 null + GSTP1 313 A/G or G/G) demonstrated further increase in the BC risk (OR = 6.64, 95 %CI = 3.63-12.16).
|
23054023 |
2013 |
|
rs536289169
|
GSTM1;GSTM2
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study we investigated the association between genetic polymorphisms with functional effects on redox regulation: Val16Ala of manganese superoxide dismutase (MnSOD), polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of glutathione S-transferase P1 (GSTP1) and myocardial infarction (MI) in a group of patients with type 2 diabetes mellitus.
|
22858312 |
2012 |
|
rs536289169
|
GSTM1;GSTM2
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
Studies focused on GSTT1 null and SOD2 Ala16Val polymorphisms gave conflicting results, while promising results came from studies on alpha1-antitrypsin in asbestosis and MPO in lung cancer.
|
18420450 |
2008 |
|
rs536289169
|
GSTM1;GSTM2
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
Studies focused on GSTT1 null and SOD2 Ala16Val polymorphisms gave conflicting results, while promising results came from studies on alpha1-antitrypsin in asbestosis and MPO in lung cancer.
|
18420450 |
2008 |
|
rs536289169
|
GSTM1;GSTM2
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
Studies focused on GSTT1 null and SOD2 Ala16Val polymorphisms gave conflicting results, while promising results came from studies on alpha1-antitrypsin in asbestosis and MPO in lung cancer.
|
18420450 |
2008 |
|
rs768623239
|
GSTM1;GSTM2
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population.
|
11757669 |
2001 |
|
rs768623239
|
GSTM1;GSTM2
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population.
|
11757669 |
2001 |
|
rs768623239
|
GSTM1;GSTM2
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population.
|
11757669 |
2001 |
|
rs536289169
|
GSTM1;GSTM2
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
C allele of C47T variant (SOD) was protective against DN, DR and microvascular complications of diabetes.
|
28548478 |
2019 |
|
rs536289169
|
GSTM1;GSTM2
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
C allele of C47T variant (SOD) was protective against DN, DR and microvascular complications of diabetes.
|
28548478 |
2019 |