rs11549465
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation |
BEFREE |
These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility.
|
31762805 |
2019 |
rs11549465
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation |
BEFREE |
Studies on HIF 1α C1772T (P582S) polymorphism revealed a genetic susceptibility to malignant tumors, however, the results were conflicting.
|
24576222 |
2014 |
rs11549465
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation |
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
rs11549465
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that HIF1A Pro582Ser</span> polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations.
|
25117331 |
2014 |
rs11549465
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation |
BEFREE |
This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.
|
24063654 |
2013 |
rs11549465
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation |
BEFREE |
The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer.
|
15538748 |
2005 |
rs11549467
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation |
BEFREE |
HIF-1α G (A588T) polymorphism has been shown to lead to genetic susceptibility to malignant tumors but results have been controversial.
|
25688508 |
2015 |
rs11549467
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation |
BEFREE |
When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC).
|
24824937 |
2014 |
rs11549467
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation |
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
rs11549467
|
HIF1A;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation |
BEFREE |
Compared with rs11549467 GG genotype, the variant genotypes GA+AA had a significantly increased PCa risk (adjusted odds ratio (OR)=1.70; 95% confidence interval (CI)=1.06-2.72), particularly among older patients (OR=2.01; 95%CI=1.05-3.86), smokers (OR=2.06; 95%CI=1.07-3.99), never drinkers (OR=2.16; 95%CI=1.20-3.86) and patients without a family history of cancer (OR=1.71; 95%CI=1.02-2.89).
|
23042446 |
2012 |
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs2057482 polymorphism was associated with decreased overall cancer risk, based on the currently available studies.
|
31744467 |
2019 |
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
Overall, C1772T and G1790A but not rs2057482 were associated with increased risk for cancer.
|
24046090 |
2014 |