DisGeNET - a database of gene-disease associations

HLA-A, major histocompatibility complex, class I, A, 3105

N. diseases: 672; N. variants: 82

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs3869062

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.720

GeneticVariation

BEFREE

In our case-control study, an association with increased risk for NPC was found for the AG vs AA genotype in HCG9 (rs3869062, A>G).

28881764

2017

dbSNP:

rs3869062

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.720

GeneticVariation

BEFREE

We confirmed the association of HLA-A to NPC with the strongest signal detected in rs3869062 (p = 1.73 × 10(-9)).

24947555

2015

dbSNP:

rs2860580

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.720

GeneticVariation

BEFREE

Finally, we applied WRSMDR to a nasopharyngeal carcinoma (NPC) case-control study and identified a statistically significant high-order interaction among three polymorphisms: rs2860580, rs11865086 and rs2305806.

24933637

2014

dbSNP:

rs3869062

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.720

GeneticVariation

GWASDB

The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove.

23209447

2012

dbSNP:

rs2860580

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.720

GeneticVariation

GWASDB

A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

20512145

2010

dbSNP:

rs3869062

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.720

GeneticVariation

GWASDB

A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

20512145

2010

dbSNP:

rs3869062

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.720

GeneticVariation

GWASDB

Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3.

19664746

2009

dbSNP:

rs2517713

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.710

GeneticVariation

BEFREE

The rs2517713 SNP located downstream of HLA-A was significantly associated with NPC (P = 1.08 × 10(-91), odds ratio [OR] = 0.58, 95 % confidence interval [CI] = 0.55-0.61).

26307051

2015

dbSNP:

rs2517713

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.710

GeneticVariation

GWASDB

The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove.

23209447

2012

dbSNP:

rs2517713

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.710

GeneticVariation

GWASDB

A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

20512145

2010

dbSNP:

rs2517713

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2931822
Disease:

Nasopharyngeal carcinoma

0.710

GeneticVariation

GWASDB

Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3.

19664746

2009

dbSNP:

rs111312615

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C0036341
Disease:

Schizophrenia

0.700

GeneticVariation

GWASCAT

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

30285260

2019

dbSNP:

rs115928623

Entrez Id:	3105;4279
Gene Symbol:	HLA-A;MICD

HLA-A;MICD

CUI:	C0003872
Disease:

Arthritis, Psoriatic

0.700

GeneticVariation

GWASCAT

Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.

30552173

2019

dbSNP:

rs192543598

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C2004491
Disease:

Cicatrix

0.700

GeneticVariation

GWASCAT

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.

31066027

2019

dbSNP:

rs192543598

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C1869024
Disease:

Severe cutaneous adverse reactions (SMQ)

0.700

GeneticVariation

GWASCAT

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.

31066027

2019

dbSNP:

rs2517873

Entrez Id:	3105;100048903
Gene Symbol:	HLA-A;MCCD1P1

HLA-A;MCCD1P1

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

GeneticVariation

GWASCAT

Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.

31326317

2019

dbSNP:

rs41546314

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C0149745
Disease:

Oral Ulcer

0.700

GeneticVariation

GWASCAT

Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.

30837455

2019

dbSNP:

rs4313034

Entrez Id:	3105;3137;80862
Gene Symbol:	HLA-A;HLA-J;ZNRD1ASP

HLA-A;HLA-J;ZNRD1ASP

CUI:	C0149745
Disease:

Oral Ulcer

0.700

GeneticVariation

GWASCAT

Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.

30837455

2019

dbSNP:

rs7749944

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C1274700
Disease:

Postmenopausal frontal fibrosing alopecia

0.700

GeneticVariation

GWASCAT

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.

30850646

2019

dbSNP:

rs7749944

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C4255374
Disease:

Frontal fibrosing alopecia

0.700

GeneticVariation

GWASCAT

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.

30850646

2019

dbSNP:

rs1061539

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C0042345
Disease:

Varicosity

0.700

GeneticVariation

GWASCAT

Clinical and Genetic Determinants of Varicose Veins.

30566020

2018

dbSNP:

rs2523933

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C0021704
Disease:

Intelligence

0.700

GeneticVariation

GWASCAT

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

29844566

2018

dbSNP:

rs2523961

Entrez Id:	3105;4279
Gene Symbol:	HLA-A;MICD

HLA-A;MICD

CUI:	C2239176
Disease:

Liver carcinoma

0.700

GeneticVariation

GWASCAT

Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

29784950

2018

dbSNP:

rs2523961

Entrez Id:	3105;4279
Gene Symbol:	HLA-A;MICD

HLA-A;MICD

CUI:	C0019163
Disease:

Hepatitis B

0.700

GeneticVariation

GWASCAT

Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

29784950

2018

dbSNP:

rs2571400

Entrez Id:	3105
Gene Symbol:	HLA-A

HLA-A

CUI:	C0021704
Disease:

Intelligence

0.700

GeneticVariation

GWASCAT

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

29844566

2018