|
rs9277378
|
HLA-DPA1;HLA-DPB1
|
Acute GVH disease
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three novel susceptibility loci in the HLA-DP region of recipient genomes that were associated with III-IV acute GvHD (rs9277378, P=1.58E-09; rs9277542, P=1.548E-06 and rs9277341, P=7.718E-05).
|
27595289 |
2017 |
|
rs9277534
|
HLA-DPB1
|
Acute GVH disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Evolutionary analysis revealed that rs9277534 represented a highly conserved HLA-DPB1 Ex3-3'UTR region and may provoke aGVHD differently to TCE mismatching algorithm, reflecting exon 2 polymorphisms.
|
29246901 |
2018 |
|
rs7750458
|
HLA-DPA1;HLA-DPB1
|
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the three SNP (rs7750458, rs9501251 and rs9500928) at 6p21.32 in the HLA-DPB1 gene were significantly associated with DM (P < 5 × 10<sup>-8</sup> ) and identified two susceptibility loci at 7q34 (PIP, rs9986765, P = 7.45 × 10<sup>-7</sup> , odds ratio [OR] = 2.71) and 10q24.2 (CPN1, rs3750716, P = 9.04 × 10<sup>-7</sup> , OR = 4.39) with suggestive evidence.
|
27153935 |
2016 |
|
rs9500928
|
HLA-DPA1;HLA-DPB1
|
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the three SNP (rs7750458, rs9501251 and rs9500928) at 6p21.32 in the HLA-DPB1 gene were significantly associated with DM (P < 5 × 10<sup>-8</sup> ) and identified two susceptibility loci at 7q34 (PIP, rs9986765, P = 7.45 × 10<sup>-7</sup> , odds ratio [OR] = 2.71) and 10q24.2 (CPN1, rs3750716, P = 9.04 × 10<sup>-7</sup> , OR = 4.39) with suggestive evidence.
|
27153935 |
2016 |
|
rs9501251
|
HLA-DPA1;HLA-DPB1
|
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the three SNP (rs7750458, rs9501251 and rs9500928) at 6p21.32 in the HLA-DPB1 gene were significantly associated with DM (P < 5 × 10<sup>-8</sup> ) and identified two susceptibility loci at 7q34 (PIP, rs9986765, P = 7.45 × 10<sup>-7</sup> , odds ratio [OR] = 2.71) and 10q24.2 (CPN1, rs3750716, P = 9.04 × 10<sup>-7</sup> , OR = 4.39) with suggestive evidence.
|
27153935 |
2016 |
|
rs3097670
|
HLA-DPA1;HLA-DPB1
|
Allergic Reaction
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
|
29083406 |
2017 |
|
rs1042151
|
HLA-DPA1;HLA-DPB1
|
Aspirin exacerbated respiratory disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In a case-control analysis, HLA-DPB1 rs1042151 (Met105Val) shows the most significant association with the susceptibility of AERD (p = 5.11 × 10(-7); OR = 2.40).
|
23180272 |
2013 |
|
rs3128965
|
HLA-DPB1
|
Aspirin exacerbated respiratory disease
|
|
0.010 |
GeneticVariation |
BEFREE |
This implies the potential of rs3128965 as a genetic marker for diagnosis and prediction of the AERD phenotype.
|
25536158 |
2014 |
|
rs386699871
|
HLA-DPA1;HLA-DPB1
|
Aspirin exacerbated respiratory disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In a case-control analysis, HLA-DPB1 rs1042151 (Met105Val) shows the most significant association with the susceptibility of AERD (p = 5.11 × 10(-7); OR = 2.40).
|
23180272 |
2013 |
|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Asthma
|
|
0.810 |
GeneticVariation |
BEFREE |
SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40).
|
21814517 |
2011 |
|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Asthma
|
C |
0.810 |
GeneticVariation |
GWASCAT |
SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40).
|
21814517 |
2011 |
|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Asthma
|
C |
0.810 |
GeneticVariation |
GWASDB |
SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40).
|
21814517 |
2011 |
|
rs3128965
|
HLA-DPB1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Comparison of rs3128965 alleles with the clinical features of asthmatics revealed that patients harboring the A allele had increased bronchial hyperresponsiveness to inhaled aspirin and methacholine, and higher 15-HETE levels, than those without the A allele (P = 0.039, 0.037, and 0.004, respectively).
|
25536158 |
2014 |
|
rs1042151
|
HLA-DPA1;HLA-DPB1
|
Asthma, Aspirin-Induced
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study of aspirin-exacerbated respiratory disease in a Korean population.
|
23180272 |
2013 |
|
rs9277534
|
HLA-DPB1
|
Autoimmune Chronic Hepatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that the HLA-DRB1*04:05 allele (P < 0.001, OR = 4.61) and rs9277534 (P = 0.004, OR = 1.67) were independently associated with AIH susceptibility. rs9277534G in the HLA-DP gene is an eQTL that affects gene expression and may contribute to AIH susceptibility.
|
30093645 |
2018 |
|
rs9277534
|
HLA-DPB1
|
Autoimmune hepatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that the HLA-DRB1*04:05 allele (P < 0.001, OR = 4.61) and rs9277534 (P = 0.004, OR = 1.67) were independently associated with AIH susceptibility. rs9277534G in the HLA-DP gene is an eQTL that affects gene expression and may contribute to AIH susceptibility.
|
30093645 |
2018 |
|
rs1042140
|
HLA-DPA1;HLA-DPB1
|
BERYLLIUM DISEASE, CHRONIC, SUSCEPTIBILITY TO
|
G |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs12722013
|
HLA-DPA1;HLA-DPB1
|
Blood Protein Measurement
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
rs9277535
|
HLA-DPB1
|
cervical cancer
|
|
0.720 |
GeneticVariation |
BEFREE |
<i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.
|
30009173 |
2018 |
|
rs9277535
|
HLA-DPB1
|
cervical cancer
|
A |
0.720 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
|
23817570 |
2013 |
|
rs9277535
|
HLA-DPB1
|
cervical cancer
|
|
0.720 |
GeneticVariation |
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
rs7770370
|
HLA-DPA1;HLA-DPB1
|
cervical cancer
|
A |
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
|
23817570 |
2013 |
|
rs9277535
|
HLA-DPB1
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
rs9277535
|
HLA-DPB1
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.
|
30009173 |
2018 |
|
rs9277535
|
HLA-DPB1
|
Complete atrioventricular block
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, rs9277535 non-GG genotype is associated with a higher likelihood of spontaneous HBsAg seroclearance in CHB patients.
|
23326374 |
2013 |