Interestingly, the effect of rs12427129 and rs3816153 on the risk of HCC could be modified by HBsAg status, while the rs12427129 CT/TT genotype could antagonize the detrimental effect of rs3816153 GT/TT genotype on HCC.
Moreover, patients with a smoking habit or younger age (≤65 years), who had at least one T allele of <i>HOTAIR</i> rs12427129 were at a higher risk of developing advance tumor T satge (<i>p</i> = 0.046), compared to those patients with CC homozygotes.
Interestingly, the effect of rs12427129 and rs3816</span>153 on the risk of HCC could be modified by HBsAg status, while the rs12427129 CT/TT genotype could antagonize the detrimental effect of r</span>s3816153 GT/TT genotype on HCC.
Among three htSNPs of the HOTAIR gene (rs12826786 C>T, rs4759314 A>G, and rs10783618 C>T), only the T allele of rs12826786 was found to increase the risk of developing GCA and was associated with smoking habit and tumor-node-metastasis (TNM) stage.