APC, APC regulator of WNT signaling pathway, 324

N. diseases: 703; N. variants: 681
Disease: Colorectal Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801166
rs1801166
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.010 GeneticVariation BEFREE The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771 1998
dbSNP: rs1463038513
rs1463038513
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The I1307K mutation is common among Jews who have had colorectal neoplasms, but overall it was found to have little effect clinically in the current study group. 15959913 2005
dbSNP: rs1801155
rs1801155
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The I1307K mutation is common among Jews who have had colorectal neoplasms, but overall it was found to have little effect clinically in the current study group. 15959913 2005
dbSNP: rs1463038513
rs1463038513
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771 1998
dbSNP: rs1463038513
rs1463038513
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE These findings support a model where somatic instability of the (A)8 tract produced by the APC I1307K allele leads to increased APC gene inactivation and directly accounts for 42% of the colorectal neoplasms occurring in APC I1307K carriers. 9751605 1998
dbSNP: rs1801155
rs1801155
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771 1998
dbSNP: rs1801155
rs1801155
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE These findings support a model where somatic instability of the (A)8 tract produced by the APC I1307K allele leads to increased APC gene inactivation and directly accounts for 42% of the colorectal neoplasms occurring in APC I1307K carriers. 9751605 1998
dbSNP: rs755229494
rs755229494
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs121913326
rs121913326
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. 24861525 2015
dbSNP: rs121913327
rs121913327
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. 24861525 2015
dbSNP: rs121913328
rs121913328
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. 24861525 2015
dbSNP: rs121913332
rs121913332
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. 24861525 2015
dbSNP: rs121913462
rs121913462
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. 24861525 2015
dbSNP: rs121913326
rs121913326
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913327
rs121913327
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913328
rs121913328
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913328
rs121913328
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer. 24518971 2014
dbSNP: rs121913329
rs121913329
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913331
rs121913331
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913332
rs121913332
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913333
rs121913333
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913333
rs121913333
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci. 24651453 2014
dbSNP: rs121913462
rs121913462
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs74535574
rs74535574
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913329
rs121913329
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing. 23700467 2013