IRGM, immunity related GTPase M, 345611

N. diseases: 57; N. variants: 13
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11749391
rs11749391
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs10065172
rs10065172
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.010 GeneticVariation BEFREE Among two tag SNPs of IRGM, no correlation was observed between rs10065172 and AS susceptibility. 28031552 2017
dbSNP: rs11747270
rs11747270
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0003864
Disease:
Arthritis 		0.010 GeneticVariation BEFREE IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD. 31654602 2020
dbSNP: rs4958847
rs4958847
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0003864
Disease:
Arthritis 		0.010 GeneticVariation BEFREE IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD. 31654602 2020
dbSNP: rs11747270
rs11747270
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. 21150878 2011
dbSNP: rs10065172
rs10065172
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0007570
Disease:
Celiac Disease 		0.010 GeneticVariation BEFREE We aimed to study the implication of five polymorphisms in these genes in CD susceptibility: rs10883365 and rs888208 in the NKX2-3 gene, rs2241880 in ATG16L1, and rs10065172 and rs4958847 in IRGM. 19683022 2009
dbSNP: rs11749391
rs11749391
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0008313
Disease:
Cholangitis, Sclerosing 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs11747270
rs11747270
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0266929
Disease:
Chronic Periodontitis 		0.010 GeneticVariation BEFREE A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis. 28983640 2018
dbSNP: rs1000113
rs1000113
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.840 GeneticVariation BEFREE Our analysis revealed an association of the IRGM SNPs rs13371189 (p = 0.02, OR 1.31 [95% CI 1.05-1.65]), rs10065172 = p.Leu105Leu (p = 0.016, OR 1.33 [95% CI 1.06-1.66]) and rs1000113 (p = 0.047, OR 1.27 [95% CI 1.01-1.61]) with CD susceptibility. 23365659 2013
dbSNP: rs1000113
rs1000113
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.840 GeneticVariation BEFREE Significant associations with Crohn's disease were noted with the T allele of rs1000113 (OR 1.46, 95% CI 1.12-1.90), T allele of rs9637876 (OR 1.25, 95% CI 1.005-1.561) and C allele of rs 13361189 (OR 1.33, 95% CI 1.07-1.669). 25191865 2014
dbSNP: rs1000113
rs1000113
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		T 0.840 GeneticVariation GWASDB Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 17554300 2007
dbSNP: rs1000113
rs1000113
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.840 GeneticVariation BEFREE We replicated the previously reported associations between CD and rs1000113 and rs4958847, confirming that IRGM is a susceptibility locus only for CD, either adult- or early-onset in the Italian population; furthermore, we have also shown its influence on specific clinical features (fistulizing disease). 19098858 2009
dbSNP: rs1000113
rs1000113
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.840 GeneticVariation BEFREE IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset CD as risk loci and defense loci, respectively. 25944217 2015
dbSNP: rs1000113
rs1000113
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		T 0.840 GeneticVariation GWASCAT Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 17554300 2007
dbSNP: rs11747270
rs11747270
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		G 0.820 GeneticVariation GWASCAT Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
dbSNP: rs11747270
rs11747270
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.820 GeneticVariation BEFREE IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD. 31654602 2020
dbSNP: rs11747270
rs11747270
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.820 GeneticVariation BEFREE Two SNPs--rs11747270 and rs180802994--did not exhibit Hardy-Weinberg equilibrium but were associated with both Crohn's disease and ulcerative colitis in this population. 25191865 2014
dbSNP: rs11747270
rs11747270
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		G 0.820 GeneticVariation GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
dbSNP: rs7714584
rs7714584
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		G 0.800 GeneticVariation GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs7714584
rs7714584
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		G 0.800 GeneticVariation GWASCAT Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs11741861
rs11741861
Entrez Id: 91975;345611
Gene Symbol: ZNF300;IRGM
ZNF300;IRGM
CUI: C0010346
Disease:
Crohn Disease 		G 0.700 GeneticVariation GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
dbSNP: rs11741861
rs11741861
Entrez Id: 91975;345611
Gene Symbol: ZNF300;IRGM
ZNF300;IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.700 GeneticVariation GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
dbSNP: rs11749391
rs11749391
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs4958847
rs4958847
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.080 GeneticVariation BEFREE IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD. 31654602 2020
dbSNP: rs4958847
rs4958847
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
CUI: C0010346
Disease:
Crohn Disease 		0.080 GeneticVariation BEFREE The analysis showed modest significant association for the rs13361189, rs4958847 and rs10065172 variants in Crohn's disease (CD): the risk estimates for the allele contrast were OR=1.306 (1.200-1.420), p=5.2 × 10(-10), OR=1.182 (1.082-1.290), p=0.0002, and OR=1.248 (1.057-1.473), p=0.009 respectively (still significant when the p value was Bonferroni adjusted to 0.017). 24232856 2013