IL6R, interleukin 6 receptor, 3570

N. diseases: 11; N. variants: 11
Source: GWASDB ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2228145
rs2228145
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0003873
Disease:
Rheumatoid Arthritis 		A 0.850 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
dbSNP: rs2228145
rs2228145
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.850 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
dbSNP: rs4129267
rs4129267
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0004096
Disease:
Asthma 		T 0.820 GeneticVariation GWASDB Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP). 21907864 2011
dbSNP: rs2228145
rs2228145
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs4129267
rs4129267
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs4129267
rs4129267
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0337428
Disease:
Fibrinogen assay 		T 0.800 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696 2013
dbSNP: rs4537545
rs4537545
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs4845625
rs4845625
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C1956346
Disease:
Coronary Artery Disease 		0.800 GeneticVariation GWASDB Large-scale association analysis identifies new risk loci for coronary artery disease. 23202125 2013
dbSNP: rs2229238
rs2229238
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0010068
Disease:
Coronary heart disease 		0.800 GeneticVariation GWASDB A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. 22319020 2012
dbSNP: rs4129267
rs4129267
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0337428
Disease:
Fibrinogen assay 		0.800 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
dbSNP: rs4129267
rs4129267
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		C 0.800 GeneticVariation GWASDB Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. 21300955 2011
dbSNP: rs4537545
rs4537545
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		T 0.800 GeneticVariation GWASDB Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. 19567438 2009
dbSNP: rs2228145
rs2228145
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. 18439548 2008
dbSNP: rs2228145
rs2228145
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C1325327
Disease:
fibrinogen activity 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs2228145
rs2228145
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C1561955
Disease:
Fibrinogen, CTCAE 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs2228145
rs2228145
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0337428
Disease:
Fibrinogen assay 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs28638007
rs28638007
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs4129267
rs4129267
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C1561955
Disease:
Fibrinogen, CTCAE 		T 0.700 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696 2013
dbSNP: rs4129267
rs4129267
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C1325327
Disease:
fibrinogen activity 		T 0.700 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696 2013
dbSNP: rs4845618
rs4845618
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs4845625
rs4845625
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs4845625
rs4845625
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C1842247
Disease:
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1 		0.700 GeneticVariation GWASDB Large-scale association analysis identifies new risk loci for coronary artery disease. 23202125 2013
dbSNP: rs7518199
rs7518199
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs7529229
rs7529229
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0201657
Disease:
C-reactive protein measurement 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291 2013
dbSNP: rs12089132
rs12089132
Entrez Id: 3570;101928101
Gene Symbol: IL6R;IL6R-AS1
IL6R;IL6R-AS1
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012