|
rs1800872
|
IL10;IL19
|
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
G |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs3021094
|
IL10;IL19
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> Our study demonstrated that A allele and A/A genotype of rs3021094 SNP in IL-10 gene were linked to increased risk for GDM, IL-10 plasma level and insulin resistance, which could be potential targets for early screening and detection of GDM.
|
30873205 |
2019 |
|
rs1800872
|
IL10;IL19
|
Gestational Diabetes
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Results:</b> There were no statistically significant differences in the distribution of <i>IL-1β</i> rs16944 and <i>IL-10</i> rs1800872 between GDM and healthy women.
|
31630588 |
2019 |
|
rs1800896
|
IL10;IL19
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>IL-10</i> -1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis.
|
28951522 |
2017 |
|
rs1800871
|
IL10;IL19
|
Behcet's uveitis
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>Results</i>: The risk allele, A, in rs1800871, of <i>IL-10</i> gene was highly prevalent in Behcet's uveitis and healthy control samples alike; highest among the Turkish groups.
|
29792538 |
2019 |
|
rs1800896
|
IL10;IL19
|
SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME
|
|
0.010 |
GeneticVariation |
BEFREE |
SCT and IL10 rs1800896, IL1A rs2856838, but not SEMA3C rs4461841, polymorphisms were associated with decreased risk of malaria in the controls.
|
29033373 |
2017 |
|
rs145922845
|
IL10;IL19
|
Crohn Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
A Gly15Arg mutation in the leader sequence of IL-10 was found in a multiple CD-affected family.
|
12825869 |
2003 |
|
rs1800896
|
IL10;IL19
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to explore the role of IL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), and TLR4_896A/G (rs4986790) polymorphisms in the susceptibility to colorectal cancer (n = 244), gastric carcinoma (n = 72), and ovarian cancer (n = 85).
|
24446182 |
2014 |
|
rs1800896
|
IL10;IL19
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to explore the role of IL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), and TLR4_896A/G (rs4986790) polymorphisms in the susceptibility to colorectal cancer (n = 244), gastric carcinoma (n = 72), and ovarian cancer (n = 85).
|
24446182 |
2014 |
|
rs1800872
|
IL10;IL19
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
A decreased risk of colorectal cancer in subjects with rs1800872 AC genotype of IL10 (OR = 0.643, 95%CI = 0.453, 0.912) or AC/CC genotype (OR = 0.636, 95%CI = 0.457, 0.885) was observed, compared with those with AA genotype.
|
24762198 |
2014 |
|
rs1800872
|
IL10;IL19
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation |
BEFREE |
A decreased risk of colorectal cancer in subjects with rs1800872 AC genotype of IL10 (OR = 0.643, 95%CI = 0.453, 0.912) or AC/CC genotype (OR = 0.636, 95%CI = 0.457, 0.885) was observed, compared with those with AA genotype.
|
24762198 |
2014 |
|
rs3024493
|
IL10;IL19
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
rs1800896
|
IL10;IL19
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation |
BEFREE |
A large number of studies have shown that the -1082A/G polymorphism (rs1800896) in the Interleukin-10 gene (IL-10) is implicated in the susceptibility to rheumatoid arthritis (RA).
|
21764596 |
2011 |
|
rs1800872
|
IL10;IL19
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation |
BEFREE |
A promoter variant (rs1800872) in the Interleukin-10 (IL-10) gene was associated with an increased lymph node metastasis involvement [odds ratio (OR) = 2.1, 95% confidence interval (CI) = 1.03-4.2, for carriers of the TT genotype].
|
21239167 |
2011 |
|
rs1800896
|
IL10;IL19
|
Inflammatory Bowel Diseases
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 101 patients diagnosed with inflammatory bowel disease were analysed for the tumour necrosis factor-alpha (-308 G/A; rs1800629) and interleukin-10 (-1082 G/A; rs1800896) gene polymorphisms.
|
27528546 |
2016 |
|
rs1800896
|
IL10;IL19
|
Nasopharyngeal carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 698 native Taiwanese consisting of 176 cases and 522 controls were enrolled in this hospital-based study, and three single-nucleotide polymorphism sites at promoter regions of IL10, A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and their interaction with smoking habit for NPC risk were evaluated.
|
23898109 |
2013 |
|
rs3021097
|
IL10;IL19
|
Nasopharyngeal carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 698 native Taiwanese consisting of 176 cases and 522 controls were enrolled in this hospital-based study, and three single-nucleotide polymorphism sites at promoter regions of IL10, A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and their interaction with smoking habit for NPC risk were evaluated.
|
23898109 |
2013 |
|
rs1800872
|
IL10;IL19
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 698 native Taiwanese consisting of 176 cases and 522 controls were enrolled in this hospital-based study, and three single-nucleotide polymorphism sites at promoter regions of IL10, A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and their interaction with smoking habit for NPC risk were evaluated.
|
23898109 |
2013 |
|
rs1800896
|
IL10;IL19
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, a statistically significant association between the IL-10 -1082A/G (rs1800896) genotype and poor survival in osteosarcoma</span> patients was observed.
|
26503210 |
2016 |
|
rs1800896
|
IL10;IL19
|
Osteosarcoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, a statistically significant association between the IL-10 -1082A/G (rs1800896) genotype and poor survival in osteosarcoma</span> patients was observed.
|
26503210 |
2016 |
|
rs1800896
|
IL10;IL19
|
Osteosarcoma of bone
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, a statistically significant association between the IL-10 -1082A/G (rs1800896) genotype and poor survival in osteosarcoma</span> patients was observed.
|
26503210 |
2016 |
|
rs1800871
|
IL10;IL19
|
Low grade glioma
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, univariate (Log-rank p = 0.019) and multivariate Cox regression analyses (p = 0.022) showed that the IL-10 rs1800871 C/T genotype correlates with improved overall survival in cases of low-grade glioma, whereas the PRKDC rs7003908 C/C genotype correlated with reduced overall and progression-free survival in high-grade glioma patients in univariate (Log-rank p = 0.000 and p = 0.000, respectively) and multivariate Cox regression analyses (p = 0.001; p = 0.002, respectively).
|
27811370 |
2016 |
|
rs1800871
|
IL10;IL19
|
Oropharyngeal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50-0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3-5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41-0.95).
|
20112337 |
2010 |
|
rs1800871
|
IL10;IL19
|
Malignant neoplasm of oropharynx
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50-0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3-5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41-0.95).
|
20112337 |
2010 |
|
rs1800871
|
IL10;IL19
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50-0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3-5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41-0.95).
|
20112337 |
2010 |