|
rs77375493
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.060 |
GeneticVariation |
BEFREE |
Although investigation for JAK2 V617F mutation is recommended in patients presenting with splanchnic venous thrombosis (SVT), no specific clinical advice is given to SVT patients presenting without myeloproliferative neoplasms (MPN) and JAK2 V617F mutation.
|
23916380 |
2013 |
|
rs77375493
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.060 |
GeneticVariation |
BEFREE |
Recent research has demonstrated in patients with MPN the existence of factors increasing the risk of SVT such as the presence of the JAK2 V617F mutation and its 46/1 haplotype.
|
23855810 |
2013 |
|
rs77375493
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.060 |
GeneticVariation |
BEFREE |
In addition, our findings in JAK2(V617F)-negative SVT patients indicate an important role for the 46/1 haplotype in the etiology and diagnosis of SVT-related MPNs, independent of JAK2(V617F), that requires further exploration.
|
21364191 |
2011 |
|
rs77375493
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.060 |
GeneticVariation |
BEFREE |
Data from a larger number of patients with long-term follow-up are needed to reveal the clinical relevancy of JAK2 V617F in Korean patients with SVT.
|
21435189 |
2011 |
|
rs77375493
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.060 |
GeneticVariation |
BEFREE |
Anticoagulation is the treatment of choice for all SVT and proper treatment of the MPD is recommended in patients with SVT associated with the JAK2(V617F) mutation.
|
19478480 |
2009 |
|
rs77375493
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.060 |
GeneticVariation |
BEFREE |
Anticoagulation therapy combined with low-dose aspirin and proper treatment of the MPD is recommended in patients with SVT associated with the JAK2(V617F) mutation.
|
17687555 |
2007 |
|
rs10974944
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.010 |
GeneticVariation |
BEFREE |
In the overall analysis, it was found that the JAK2 46/1 haplotype significantly elevated the risk of MPNs (rs10974944: C vs T: odds ratio (OR) = 2.19, 95 % confidence interval (CI) = 1.86-2.57, P < 0.0001; CC vs TT: OR = 4.63, 95 % CI = 3.32-6.47, P < 0.0001; CT vs TT: OR = 2.49, 95 % CI = 2.11-2.95, P < 0.0001; (CC + CT) vs TT: OR = 2.92, 95 % CI = 2.51-3.39, P < 0.0001; rs12343867: C vs T: OR = 1.88, 95 % CI = 1.59-2.22, P < 0.0001; CC vs TT: OR = 3.16, 95 %CI = 2.14-4.65, P < 0.0001; CT vs TT: OR = 2.04, 95 % CI = 1.51-2.74, P < 0.0001; (CC + CT) vs TT: OR = 2.25, 95 % CI = 1.73-2.95, P < 0.0001) and SVT (C vs T: OR = 1.27, 95 % CI = 1.06-1.52, P = 0.011; CC vs TT: OR = 2.33, 95 % CI = 1.42-3.81, P = 0.001; (CC + CT) vs TT: OR = 1.25, 95 % CI = 1.02-1.53, P = 0.034).
|
25015051 |
2014 |
|
rs12343867
|
JAK2;INSL6
|
Supraventricular tachycardia
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no evidence of a significant association between the rs12343867 and the risk of SVT in the genetic model (CT vs TT: OR = 1.01, 95 % CI = 0.80-1.29, P = 0.906).
|
25015051 |
2014 |