|
rs75070487
|
KCNMB1;KCNIP1;KCNIP1-OT1
|
Schizophrenia
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study of paliperidone efficacy.
|
27846195 |
2017 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
The results suggest that profiling patients at Glu65Lys can assist in gauging renal prognosis as well as selection of rational therapy in hypertension with progressive renal disease.
|
20861615 |
2010 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
Moreover, the epidemiological studies showed that the presence of the E65K polymorphism in, e.g., BKCa beta1-subunit gene (producing a "gain-of-function") lowers the prevalence for severe hypertension and myocardial infarction.
|
20043229 |
2010 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
We also found that the carriers of minor T allele of KCNMB1-rs11739136 had a significantly decreased risk for hypertension (TT+CT vs. CC; odds ratio=0.83; 95% confidence interval, 0.72-0.95; P value after the Bonferroni correction=0.008 x 5=0.040).
|
18496125 |
2008 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
The previous studies have, however, been conflicting, and the aim of the present study was to clarify the impact of the Glu65Lys polymorphism on hypertension at the population level of middle-aged people.
|
18854753 |
2008 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Essential Hypertension
|
|
0.020 |
GeneticVariation |
BEFREE |
The dominant model of KCNJ11 E23K and KCNMB1 E65K might be susceptible factors for essential hypertension.
|
31169684 |
2019 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Essential Hypertension
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotype and allele frequency analyses revealed that the frequency of genotypes KCNJ11-rs2285676 and KCNMB1-rs11739136 was not significantly different between the EH and NT groups.
|
28962116 |
2017 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, the epidemiological studies showed that the presence of the E65K polymorphism in, e.g., BKCa beta1-subunit gene (producing a "gain-of-function") lowers the prevalence for severe hypertension and myocardial infarction.
|
20043229 |
2010 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Diastolic hypertension
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs11739136 KCNMB1 Glu65Lys polymorphism in the beta1 subunit of the Ca2+ and voltage-dependent potassium channel has, in some studies, been reported to associate with a protective effect on diastolic hypertension.
|
18854753 |
2008 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study provides the first genetic evidence for the different impact of the BK channel in the control of human blood pressure in men and women, with particular relevance in aging women, and highlights the E65K polymorphism as one of the strongest genetic factors associated thus far to protection against myocardial infarction and stroke.
|
16293791 |
2005 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Diastolic hypertension
|
|
0.020 |
GeneticVariation |
BEFREE |
Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.
|
16293791 |
2005 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Kidney Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
The results suggest that profiling patients at Glu65Lys can assist in gauging renal prognosis as well as selection of rational therapy in hypertension with progressive renal disease.
|
20861615 |
2010 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Kidney Failure
|
|
0.010 |
GeneticVariation |
BEFREE |
Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
|
20861615 |
2010 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
|
20861615 |
2010 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Nephrosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
We explored Glu65Lys effects on GFR in three populations spanning two ethnicities and two diseases (hypertension and nephrosclerosis).
|
20861615 |
2010 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides the first genetic evidence for the different impact of the BK channel in the control of human blood pressure in men and women, with particular relevance in aging women, and highlights the E65K polymorphism as one of the strongest genetic factors associated thus far to protection against myocardial infarction and stroke.
|
16293791 |
2005 |
|
rs11739136
|
KCNMB1;KCNIP1
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
We now report the modulatory effect of sex and age on the association of the E65K polymorphism with low prevalence of diastolic hypertension and the protective role of E65K polymorphism against cardiovascular disease.
|
16293791 |
2005 |