KLK2, kallikrein related peptidase 2, 3817

N. diseases: 43; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6070
rs6070
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0201544
Disease:
Prostate specific antigen measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. 28139693 2017
dbSNP: rs6070
rs6070
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0201544
Disease:
Prostate specific antigen measurement 		A 0.700 GeneticVariation GWASCAT Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. 28139693 2017
dbSNP: rs198972
rs198972
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0201544
Disease:
Prostate specific antigen measurement 		0.700 GeneticVariation GWASDB Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA. 23359319 2013
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.040 GeneticVariation BEFREE The T allele of rs198977, a single nucleotide polymorphism in exon 5 of KLK2, codes for W-hK2 and is associated with lower serum hK2 levels and higher risk of prostate cancer than the C allele encoding R-hK2. 25847286 2015
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE The T allele of rs198977, a single nucleotide polymorphism in exon 5 of KLK2, codes for W-hK2 and is associated with lower serum hK2 levels and higher risk of prostate cancer than the C allele encoding R-hK2. 25847286 2015
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.040 GeneticVariation BEFREE This exploratory analysis in prostate cancer patients revealed the W allele of the KLK2 R250W SNP to be less likely associated with low GS morphology. 21178268 2010
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE This exploratory analysis in prostate cancer patients revealed the W allele of the KLK2 R250W SNP to be less likely associated with low GS morphology. 21178268 2010
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.040 GeneticVariation BEFREE Among the SNPs studied, the A allele of the KLK2-SNP1 (G>A, rs2664155) and the T allele of the KLK2-SNP5 (C>T, rs198977) polymorphisms showed positive associations with prostate cancer, adjusted ORs for KLK2-SNP1 AG and AA genotypes being 1.4 [95% confidence interval (95% CI), 1.2-1.8; P=0.002] and for KLK2-SNP5 TT or CT genotypes being 1.3 (95% CI, 1.1-1.6; P=0.05). 17085659 2006
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE Among the SNPs studied, the A allele of the KLK2-SNP1 (G>A, rs2664155) and the T allele of the KLK2-SNP5 (C>T, rs198977) polymorphisms showed positive associations with prostate cancer, adjusted ORs for KLK2-SNP1 AG and AA genotypes being 1.4 [95% confidence interval (95% CI), 1.2-1.8; P=0.002] and for KLK2-SNP5 TT or CT genotypes being 1.3 (95% CI, 1.1-1.6; P=0.05). 17085659 2006
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.040 GeneticVariation BEFREE Our results suggest that the C allele of the functional C748T polymorphism of KLK2 may increase the risk of PCa. 15643194 2005
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE Our results suggest that the C allele of the functional C748T polymorphism of KLK2 may increase the risk of PCa. 15643194 2005
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.010 GeneticVariation BEFREE A T allele at rs198977 in KLK2 was associated with increased cancer risk and a striking decrease of hK2 levels in blood. 20424135 2010
dbSNP: rs198977
rs198977
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE A T allele at rs198977 in KLK2 was associated with increased cancer risk and a striking decrease of hK2 levels in blood. 20424135 2010
dbSNP: rs2664155
rs2664155
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE Among the SNPs studied, the A allele of the KLK2-SNP1 (G>A, rs2664155) and the T allele of the KLK2-SNP5 (C>T, rs198977) polymorphisms showed positive associations with prostate cancer, adjusted ORs for KLK2-SNP1 AG and AA genotypes being 1.4 [95% confidence interval (95% CI), 1.2-1.8; P=0.002] and for KLK2-SNP5 TT or CT genotypes being 1.3 (95% CI, 1.1-1.6; P=0.05). 17085659 2006
dbSNP: rs2664155
rs2664155
Entrez Id: 3817
Gene Symbol: KLK2
KLK2
CUI: C0600139
Disease:
Prostate carcinoma 		0.010 GeneticVariation BEFREE Among the SNPs studied, the A allele of the KLK2-SNP1 (G>A, rs2664155) and the T allele of the KLK2-SNP5 (C>T, rs198977) polymorphisms showed positive associations with prostate cancer, adjusted ORs for KLK2-SNP1 AG and AA genotypes being 1.4 [95% confidence interval (95% CI), 1.2-1.8; P=0.002] and for KLK2-SNP5 TT or CT genotypes being 1.3 (95% CI, 1.1-1.6; P=0.05). 17085659 2006