LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Disease: Myocardial Infarction ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0027051
Disease:
Myocardial Infarction 		G 0.710 GeneticVariation GWASCAT A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. 26343387 2015
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0027051
Disease:
Myocardial Infarction 		0.710 GeneticVariation BEFREE Extreme lipoprotein(a) levels or corresponding LPA KIV-2/rs10455872 risk genotypes substantially improved MI and CHD risk prediction. 23375930 2013
dbSNP: rs3798220
rs3798220
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0027051
Disease:
Myocardial Infarction 		0.020 GeneticVariation BEFREE We also found three SNPs rs1122608, rs3798220 and rs579459 were significantly associated with risk factors of MI, although they had no association with MI in Chinese population. 24475106 2014
dbSNP: rs3798220
rs3798220
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0027051
Disease:
Myocardial Infarction 		0.020 GeneticVariation BEFREE Using predefined cutpoints for extreme lipoprotein(a) levels and/or corresponding LPA risk genotypes (kringle IV type 2 [KIV-2]) repeat polymorphism, rs3798220, and rs10455872 single nucleotide polymorphisms), we calculated net reclassification indices from <10% to 10% to 19.9% to ≥20% absolute 10-year MI and CHD risk. 23375930 2013