LTA4H, leukotriene A4 hydrolase, 4048

N. diseases: 63; N. variants: 11
Disease: Myocardial Infarction ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2540487
rs2540487
Entrez Id: 4048
Gene Symbol: LTA4H
LTA4H
CUI: C0027051
Disease:
Myocardial Infarction 		0.010 GeneticVariation BEFREE The rs2540487 genotype was associated with the risk of MI in overdominant model (P = 0.008). rs12762303 and rs10507391 SNPs were significantly associated with lipid levels in MI patients (P < 0.006-0.008). 30678701 2019
dbSNP: rs2247570
rs2247570
Entrez Id: 4048
Gene Symbol: LTA4H
LTA4H
CUI: C0027051
Disease:
Myocardial Infarction 		0.010 GeneticVariation BEFREE In FLAP, two SNPs were negatively associated with incident MI (rs9551963 & rs17222842) while one SNP (rs2247570) located in LTA4-H, was associated with higher risk of MI when comparing subjects with two copies of the variant allele to homozygotes for the wild type. 27893808 2016